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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1976 - no further detail available
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientifically acceptable
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report Date:
1976

Materials and methods

Test guideline
Qualifier:
no guideline followed
Deviations:
not applicable
Principles of method if other than guideline:
no further information
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
no data
No. of animals per sex per dose:
10 animals per dose
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
14 800 mg/kg bw
Remarks on result:
other: after 10 days
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 16 000 mg/kg bw
Remarks on result:
other: after 24 h
Sex:
not specified
Dose descriptor:
other: LD 10
Effect level:
ca. 9 900 mg/kg bw
Remarks on result:
other: after 10 days
Sex:
not specified
Dose descriptor:
other: LD10
Effect level:
> 16 000 mg/kg bw
Remarks on result:
other: after 24 h
Sex:
not specified
Dose descriptor:
other: LD 90
Effect level:
> 16 000 mg/kg bw
Remarks on result:
other: after 10 days

Any other information on results incl. tables

no additional remarks

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Thiotiamin can not be classified as toxic under the described test conditions
Executive summary:

The tests were carried out by using 10 animals per dosage group. The routes of adninistration were oral (by gavage). The lethal doses were determined by the computer method developed by Dr S. Wolf. The LD 10, LD 50, and LD 90 are stated for observation periods of 24 hours and of 10 days. The LD 50 value for Thiotiamin was found to be 14800 mg/kg bw (after 10 days).