Magnesium perchlorate

Endpoint summary

Description of key information

acute tox (oral) LD50 = 1490 mg/kg b.w. (prediction by OECD QSAR Toolbox v4.3.1, 2019; based on experimental results of closely related analogues Potassium perchlorate and Lithium perchlorate)

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Remarks:

in silico, (Q)SAR performed with OECD QSAR Toolbox, Read Across analysis

Type of information:

other: (Q)SAR from supporting substances (structural analogues or surrogates) for which an experimental result is available

Adequacy of study:

key study

Study period:

2019-03-29

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification, with an experimental result (as provided by the OECD QSAR Toolbox)

Justification for type of information:

1. SOFTWARE
OECD QSAR Toolbox v4.3.1

2. MODEL (incl. version number)
Read Across analysis

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
[Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Please refer to 'Attached justification'

5. APPLICABILITY DOMAIN
Please refer to 'Attached justification'

Guideline:

other: ECHA Guidance R.6

Principles of method if other than guideline:

- Software tool(s) used including version: OECD QSAR Toolbox v4.3.1
- Model(s) used: Read Across analysis
- Model description: see field 'Justification for non-standard information' and 'Attached justification'
- Justification of QSAR prediction: see field 'Justification for type of information' and 'Attached justification'

GLP compliance:

no

Remarks:

Not applicable (QSAR calculation)

Specific details on test material used for the study:

[Mg+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O

Species:

other: rodent

Route of administration:

oral: unspecified

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

1 490 mg/kg bw

Based on:

test mat.

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The acute oral toxicity of Magnesium perchlorate to rodents was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the analogues Potassium Potassium perchlorate (CAS 7778-74-7) and Lithium perchlorate (CAS 7791-03-9). Since the perchlorate is considered to trigger the toxicity, this approach is justified. The predicted LC50 is 1490 mg/kg bw.

Predictions by the OECD QSAR Toolbox v4.3.1 with experimental result(s) of closely related perchlorate(s) with CAS 7778-74-7 and 7791-03-9 contained therein are used to address the endpoint, which is entirely appropriate to draw conclusions on the acute toxicity of Magnesium perchlorate by the oral route.

The predicted LD50 of 1490 mg/kg b.w. is above the limit value of 300 mg/kg b.w. and below the limit value of 2000 mg/kg b.w., wherefore Magnesium perchlorate needs to be classified as acute tox. 4 according to Regulation 1272/2008 and amendments.

Executive summary:

The acute oral toxicity of magnesium perchlorate to rodents was calculated with OECD QSAR Toolbox v4.3.1 by read-across analysis using the analogues potassium perchlorate and lithium perchlorate. Since the perchlorate is considered to trigger the toxicity this read-across approach is justified. The predicted LC₅₀ is 1490 mg/kg bw.

Predictions by the OECD QSAR Toolbox v4.3.1 with experimental result(s) of closely related perchlorate(s) with CAS 7778-74-7 and 7791-03-9 contained therein are used to address the endpoint, which is entirely appropriate to draw conclusions on the acute toxicity of Magnesium perchlorate by the oral route.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

1 490 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

The acute oral toxicity of Magnesium perchlorate to rodents was predicted with OECD QSAR Toolbox v4.3.1 using experimental results of the closely analogue substances Potassium perchlorate (CAS 7778-74-7) and Lithium perchlorate (CAS 7791-03-9). These analogue substances were tested for their acute oral toxicity to rodents according to OECD TG 423 (GLP). Since the perchlorate is considered to trigger the toxicity, this approach is justified and considered as entirely appropriate to draw conclusions on the acute toxicity of Magnesium perchlorate by the oral route. However, the registrant is prepared to conduct an experimental study but considered it as not necessary at first instance taking into account the available results.

Justification for classification or non-classification

The predicted LD₅₀ of 1490 mg/kg b.w. is above the limit value of 300 mg/kg b.w. and below the limit value of 2000 mg/kg b.w., wherefore Magnesium perchlorate needs to be classified as acute tox. 4 according to Regulation 1272/2008 and amendments.