Registration Dossier
Registration Dossier
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EC number: 265-332-2 | CAS number: 65059-42-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019.03.12~2019.05.21
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- adopted 17th DEC 2001
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Trimethyloctylammonium methyl sulphate
- EC Number:
- 265-332-2
- EC Name:
- Trimethyloctylammonium methyl sulphate
- Cas Number:
- 65059-42-9
- Molecular formula:
- C11H26N.CH3O4S
- IUPAC Name:
- trimethyl(octyl)azanium methyl sulfate
- Test material form:
- solid: bulk
1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Remarks:
- RAT, SPF
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Sterile distilled water
- Details on oral exposure:
- This vehicle has been used widely in toxicity study.
Before the study initiation date, this vehicle was chosen
as appropriate vehicle of test substance preparation through
the vehicle test. - Doses:
- 300mg/kg ~ 2,000mg/kg B.W
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The test substance-related dead animals were observed in the dose of 2000 mg/kg
body weight (3rd step) at 3 animals (2301 – 2303 : 1 day). - Clinical signs:
- other: In clinical signs, soiled perineal region [(2103 : 1 day) / (2201, 2203 : 1 day)] were observed in the dose of 300 mg/kg body weight (1st , 2nd step).
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on these results, Trimethyloctylammonium methyl sulphate was classified into
GHS (Globally Harmonized Classification System for Chemical Substances and
Mixtures) Category 4 (300 mg/kg body weight < LD50 < 2000 mg/kg body weight) in
this study.
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