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Diss Factsheets
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EC number: 701-299-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Remarks:
- Pre-GLP study, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- pre-guideline study
- Deviations:
- yes
- Remarks:
- 24h occlusive exposure, only two readings at 24 and 72 h, scarified/abraded skin included
- Principles of method if other than guideline:
- The test procedure follows the test method described in "METHOD OF TESTING PRIMARY IRRITANT SUBSTANCES" from US Code of Federal Regulations (CFR) Title 16, Section 1500.41, which is comparable to OECD TG 404.
- GLP compliance:
- no
- Remarks:
- pre-GLP study
Test material
- Reference substance name:
- Naphtha (petroleum), steam-cracked, C8-10 aromatic hydrocarbon fraction, alkylated and oligomerised
- EC Number:
- 701-299-7
- Molecular formula:
- not applicable (depends on the monomers; see "Structural formula")
- IUPAC Name:
- Naphtha (petroleum), steam-cracked, C8-10 aromatic hydrocarbon fraction, alkylated and oligomerised
- Test material form:
- liquid: viscous
- Details on test material:
- - Manufacturers identification: Novares TL 10, Novares L 100, Novares L 800, Novares C 10 (different types/technical products of the substance)
- Substance type: organic
- Test material is 'Naphtha (petroleum), steam-cracked, C8-10 aromatic hydrocarbon fraction, alkylated and oligomerised', EC list number 701-299-7 (assigned by ECHA after request for change of EC number/EC name). Originally, the substance Hydrocarbons, C9-unsaturated, polymerised, CAS No. 71302- 83-5, was submitted for registration. Subsequent to substance validation, the identity of the substance was changed by ECHA (EC number 615-276-2 and new name 'Distillates (petroleum), steam-cracked, C8-12 fraction", mainly C8 - C10 unsaturated aromatic and alkylaromatic hydrocarbons, predominantly styrene- and indene-derivatives, obtained by Lewis acid-initiated alkylation and polymerisation').
- for additional information see respective study records
1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Produkt-Nr.: 161 001 (additional name: Cumaron-Inden Harz B1 flüssig) (early technical product of the substance 'Naphtha (petroleum), steam-cracked, C8-10 aromatic hydrocarbon fraction, alkylated and oligomerised')
- no further information
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Remarks:
- albino rabbit
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Details unknown
ENVIRONMENTAL CONDITIONS
- Details unknown
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded or intact and shaved
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- according to method description in study report
- Controls:
- not required
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 1 inch x 1 inch
- % coverage: no data
- Type of wrap if used: the test material is covered with surgical gauze, two single layers thick. In addition, the entire trunk of the animal is wrapped with an impervious material such as rubberised cloth
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
OBSERVATION TIME POINTS
- after removal of patches/cover and 48 hrs thereafter; 24 and 72 hrs after application
SCORING SYSTEM (see method description in the test report under 'Attached full study report')
- Evaluation of skin irritation: skin effects are evaluated according to the scoring system of Draize
- Method of calculation: primary irritation score is calculated according to the procedure described in the test method
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Remarks:
- over 6 animal, two time points and two application forms: total of individual scores for erythema and oedema divided by (6x4)
- Time point:
- other: 24 + 72 h
- Score:
- 1.5
- Max. score:
- 8
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 24 h
- Score:
- 0.833
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks:
- observation period is only 72 hrs; with regard to the low erythema score, full reversibility is expected within a period of 14 days
- Remarks on result:
- other: maximum erythema score was 1 (5 animals)
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks:
- observation period is only 72 hrs; with regard to the low erythema score, full reversibility is expected within a period of 14 days
- Remarks on result:
- other: maximum erythema score was 1 (6 animals)
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 24 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks:
- observation period is only 72 hrs; with regard to the low edema score, full reversibility is expected within a period of 14 days
- Remarks on result:
- other: maximum edema score was 1 (3 animals)
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 6 animals
- Time point:
- 72 h
- Score:
- 0.167
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks:
- observation period is only 72 hrs; with regard to the low edema score, full reversibility is expected within a period of 14 days
- Remarks on result:
- other: maximum edema score was 1 (1 animal)
- Irritant / corrosive response data:
- Six animals were tested for skin irritation response. The maximum score observed for erythema and edema was 1 (total maximum score 4). For erythema, no decline was noted from observation at 24 hrs to the observation at 72 hrs. But due to the only slight erythema formation (maximum grade 1), it is expected that effects are fully reversible withinan observation period of 14 days.
For edema formation, a substantial decline of effects was noted from the observation at 24 hrs to the reading at 72 hrs (at 24 hrs 3 animals with score 1, at 72 hrs only 1 animal with score 1). Effects are expected to be fully reversible.
All readings are summaries in the table under 'Any other information on results incl. tables'.
Any other information on results incl. tables
Individual scores
Animal # |
Skin effect |
24 hours |
72 hours |
||
Left side |
Right side |
Left side |
Right side |
||
1 |
Erythema |
1 |
1 |
1 |
1 |
Oedema |
1 |
1 |
0 |
0 |
|
2 |
Erythema |
0 |
0 |
1 |
1 |
Oedema |
1 |
1 |
0 |
1 |
|
3 |
Erythema |
1 |
1 |
1 |
1 |
Oedema |
0 |
1 |
0 |
1 |
|
4 |
Erythema |
1 |
1 |
1 |
1 |
Oedema |
0 |
1 |
0 |
1 |
|
5 |
Erythema |
1 |
1 |
1 |
1 |
Oedema |
1 |
1 |
1 |
1 |
|
6 |
Erythema |
1 |
1 |
1 |
1 |
Oedema |
0 |
1 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: study not suited for classification; results observed in the study provide strong evidence that the substance is not irritating to skin.
- Conclusions:
- It can be concluded that this technical product representing the substance NAF-AO is not irritating under current test standards.
- Executive summary:
In this study, the test material was applied to the skin of six rabbits for 24 hours. The rabbits were observed over 72 hours with readings at 24 and 72 hours after application. Results indicate that the test material caused slight irritation to the skin under test conditions, not classifiable to current standards. But taking into account the overall irritating response, it is assessed that criteria for skin irritation according to CLP regulation are not met.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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