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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: ECHA provided robust study summary
Qualifier:
according to guideline
Guideline:
other: Method C2, 92/69/EEC
GLP compliance:
yes
Analytical monitoring:
yes
Details on sampling:
The test solutions were prepared at nominal concentrations of 5.6, 10, 18, 32, 56 and 100 mg/l. The 18, 32, 56 and 100 mg/l nominal levels were analysed at 0 h and 48 h.
Vehicle:
not specified
Test organisms (species):
Daphnia magna
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Nominal and measured concentrations:
Nominal concentrations: 5.6, 10, 18, 32, 56, 100 mg/L
Measured concentrations: within 90% of the nominal concentration
Reference substance (positive control):
not specified
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
29 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
18 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EC100
Effect conc.:
56 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Validity criteria fulfilled:
yes
Conclusions:
The 48h-EC50 of Daphnia magna was 29 mg/L.
Executive summary:

The study was conducted according to Method C2, 92/69/EEC. The Daphnia were exposed for a maximum of 48 hours to a range of nominal concentrations from 5.6 to 100 mg/L, increasing by a factor of 1.8. The mobility of the daphnids was recorded at 24 and 48 hours. Samples for chemical analysis of the test item concentrations were taken at the start and the end of the test. Analysis of the samples taken during the test showed that the measured concentrations were in agreement with nominal and could be maintained at 90% of the initial concentration. The test item did not induce acute immobilisation of Daphnia magna at 18 mg/L after 48 hours of exposure (NOEC). The 48h-EC50 was 29 mg/L. Based on this study the test item is not classified as harmful to aquatic organisms.

Description of key information

The 48h-EC50 of Daphnia magna was 29 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
29 mg/L

Additional information

The study was conducted according to Method C2, 92/69/EEC. The Daphnia were exposed for a maximum of 48 hours to a range of nominal concentrations from 5.6 to 100 mg/L, increasing by a factor of 1.8. The mobility of the daphnids was recorded at 24 and 48 hours. Samples for chemical analysis of the test item concentrations were taken at the start and the end of the test. Analysis of the samples taken during the test showed that the measured concentrations were in agreement with nominal and could be maintained at 90% of the initial concentration. The test item did not induce acute immobilisation of Daphnia magna at 18 mg/L after 48 hours of exposure (NOEC). The 48h-EC50 was 29 mg/L. Based on this study the test item is not classified as harmful to aquatic organisms.