Registration Dossier
Registration Dossier
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EC number: 481-830-4 | CAS number: 3687-22-7
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- other: read across
- Title:
- Unnamed
- Year:
- 2 010
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- read across
- GLP compliance:
- no
Test material
- Details on test material:
- read across
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Brown Norway
Results and discussion
Results: maternal animals
General toxicity (maternal animals)
- Details on results:
Kidney Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Liver Pathology and Weight ; First generation adult parental animals( P1)
Liver Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Kidney Pathology and Weight ; First generation adult parental animals( P1)
Decrease in Implantations ; First generation adult parental animals( P1)
Decrease in Implantations ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Decreased Litter Size ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Ovary Pathology and Weight ; First generation adult parental animals( P1)
Ovary Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Kidney Pathology and Weight ; First generation adult parental animals( P1)
Kidney Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Liver Pathology and Weight ; First generation adult parental animals( P1)
Liver Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Effect levels (maternal animals)
- Remarks on result:
- not measured/tested
Results (fetuses)
Effect levels (fetuses)
- Dose descriptor:
- LOEL
- Effect level:
- 665 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
Kidney Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Liver Pathology and Weight ; First generation adult parental animals( P1)
Liver Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Kidney Pathology and Weight ; First generation adult parental animals( P1)
Decrease in Implantations ; First generation adult parental animals( P1)
Decrease in Implantations ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Decreased Litter Size ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Ovary Pathology and Weight ; First generation adult parental animals( P1)
Ovary Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Kidney Pathology and Weight ; First generation adult parental animals( P1)
Kidney Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Liver Pathology and Weight ; First generation adult parental animals( P1)
Liver Pathology and Weight ; Second generation adult parental animals or first generation juvenile (young) offspring from P1 adult animals (specific to effect)( F1)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
