Registration Dossier
Registration Dossier
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EC number: 481-830-4 | CAS number: 3687-22-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- other: SNIF
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 008
- Reference Type:
- other: SNIF#001-4.1.30-01
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V.
- GLP compliance:
- yes
- Limit test:
- yes
Test material
Constituent 1
Test animals
- Species:
- other: Rat, Sprague-Dawley
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: None.
- Duration of exposure:
- 24 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels:
No clinical signs were observed during the study. - Gross pathology:
- Effects on organs:
No apparent abnormalities were observed at necropsy in any
animal. - Other findings:
- Signs of toxicity (local):
A yellow coloration of the skin was noted in all the animals
throughout the observation period. This coloration masked
the evaluation of cutaneous reactions between day 2 and day
5 or 6.
A dryness of the skin and crusts were noted in all the
animals between day 5 and day 15 (end of the observation
period).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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