Registration Dossier
Registration Dossier
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EC number: 481-830-4 | CAS number: 3687-22-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- other: SNIF
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 008
- Reference Type:
- other: SNIF#001-43.10-01
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V.
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella typhimurium: TA 1535, TA 1537, TA 98, TA 100 and TA 102 strains.
- Metabolic activation system:
- The S9 mix prepared from a liver microsomal fraction (S9 mix) of rats induced with Aroclor 1254.
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): .313 ... 20 µg/plate
Concentration range in the main test (without metabolic activation): .156 ... 10 µg/plate - Vehicle / solvent:
- Solvent: Dimethylsulfoxide (DMSO)
- Details on test system and experimental conditions:
- Concentration of the test substance resulting in precipitation: 500 µg/plate
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (>= 10 µg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (>= 10 µg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (>= 2.5 µg/plate)
- Remarks on result:
- other: other: preliminary test
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Data from SNIF
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
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