Diethyl bis(2-hydroxyethyl)aminomethylphosphonate

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 23 May 2018 to 08 January 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

July 1995

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

May 2006

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Remarks:

The water solubility of the test item in demineralized water in ratios 1:10, 1:1 and 10:1 is observed in a preliminary test.

Key result

Water solubility:

> 1 000 g/L

Incubation duration:

24 h

Remarks on result:

other: Temperature not specified but assumed to be ambient. pH not recorded.

In all three flasks no phase separation could be observed after the flasks were allowed to stand for 24 hours. Therefore the water solubility is stated as soluble with demineralized water in any ratio. The test substance was soluble in > 1000 g/L.

In each test solution, the presence of the test item was confirmed by HPLC-MS after standing for one hour to prove that the test item is stable in aqueous solution.

Conclusions:

The substance is regarded as fully miscible.

Executive summary:

The water solubility of the test item was investigated according to OECD105/EU A6 guidelines, under GLP.

In a preliminary test, ratios of 1:10, 1:1 and 10:1 of the test item in demineralized water were prepared, and turned to homogeneous solutions, stable for at least one hour as confirmed by HPLC-MS.

As the solubility was determined to be > 1000 g/L, no further testing was performed.

Reference 2

Endpoint:

water solubility

Type of information:

not specified

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Principles of method if other than guideline:

not specified

GLP compliance:

not specified

Other quality assurance:

other: not specified

Type of method:

other: not specified

Key result

Water solubility:

> 1 000 g/L

Remarks on result:

other: highly soluble

Remarks:

Temperature was not reported

Details on results:

General classification based on Water Solubility is: "Very soluble" means "higher than 1000 g/L"

Executive summary:

In the GESTIS database, Diethyl bis(2-hydroxyethyl)aminomethylphosphonate is reported as very soluble in water (> 1000 g/L).

Description of key information

The water solubility of the substance has been measured > 1000 g/L. (OECD 105, flask preliminary test; Holzaht-Grimme 2019; GLP).
The maximum solubility, extrapolated to be fully miscible, corresponds to the density value.

Key value for chemical safety assessment

Water solubility:

1 161 g/L

at the temperature of:

20 °C

Additional information

A fully reliable, GLP preliminary testing is available, and confirm the qualitative assessment from literature as very soluble. However, only a limit value was provided (> 1000 g/L), as not tested above a 10:1 ratio. Extrapolating this result to fully miscible at any ratio, the theoretical maximum solubility would be equivalent to the density of the substance (i.e. 1 drop of water dissolving all the amount of substance). As presented in this IUCLID Section 4.4, the relative density D20/4 was measured to be 1,161, that would represent 1161 g/L, à 20°C. This value is retained as key data.