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EC number: 218-964-8
CAS number: 2304-30-5
An AMES test was performed according to the OECD guideline 471 and GLP
principles. All bacterial strains showed negative responses up to and
including 5000 ug/plate, i.e. no significant dose-related increase in
the number of revertants with or without metabolic activation was seen.
No cytotoxicity and/or precipitation of the test substance was observed
in the direct-plate experiment. In the pre-incubation assay, toxicity
was observed in all tester strains in the absence of S9-mix and in
tester strain TA100 in the presence of S9-mix at the two highest
concentrations tested. The negative and strain-specific positive control
values were within the laboratory historical control data ranges
indicating that the test conditions were adequate and that the metabolic
activation system functioned properly.
Based on the results of this study it is concluded that
Tetrabutylphosphonium Bromide; CYPHOS® 442 Phosphonium Salt is not
mutagenic in the Salmonella typhimurium reverse mutation assay and in
the Escherichia coli reverse mutation assay with or without metabolic
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