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EC number: 218-964-8
CAS number: 2304-30-5
Reliable Ames test performed according to OECD 471 guideline and in
accordance with GLP principles with and without metabolic activation.
An AMES test was performed according to the OECD guideline 471 and GLP
principles. All bacterial strains showed negative responses up to and
including 5000 ug/plate, i.e. no significant dose-related increase in
the number of revertants with or without metabolic activation was seen.
No cytotoxicity and/or precipitation of the test substance was observed
in the direct-plate experiment. In the pre-incubation assay, toxicity
was observed in all tester strains in the absence of S9-mix and in
tester strain TA100 in the presence of S9-mix at the two highest
concentrations tested. The negative and strain-specific positive control
values were within the laboratory historical control data ranges
indicating that the test conditions were adequate and that the metabolic
activation system functioned properly.
Based on the results of this study it is concluded that
Tetrabutylphosphonium Bromide; CYPHOS® 442 Phosphonium Salt is not
mutagenic in the Salmonella typhimurium reverse mutation assay and in
the Escherichia coli reverse mutation assay with or without metabolic
Based on the results of this study it is concluded that the analogue
substance is not mutagenic in the Salmonella typhimurium reverse
mutation assay and in the Escherichia coli reverse mutation assay with
or without metabolic activation.
Based on the available data, Tetrabutylphosphonium Chloride is not
classified for genotoxicity according to the Globally Harmonized System
of Classification and Labelling of Chemicals (GHS) of the United Nations
(2011) (including all amendments) and CLP Regulation EC (No.) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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