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EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Study period:
- 6 March to 26 June 2018
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Log Pow was calculated using Estimation Program Interface EPI ver. 4.1.
- Type of method:
- estimation method (solubility ratio)
- Specific details on test material used for the study:
- Name:
CAS No.: Oleyl Lactate (Dermol OL)
42175-36-0 (formally known as)
EC NO:
Chemical Name
Physical state: 946-088-2 (assigned since pre-registration)
Reaction Products of (Z)-octadec-9-enol and lactic acid
Clear yellow liquid
Sponsor lot number: P7610
Purity: 100%
Molecular weight: 340.5405 g/mol
Arrival date: 7 February 2018
Re-test date: 31 January 2020
Storage conditions: Room temperature (15 to 30°C) - Type:
- log Pow
- Partition coefficient:
- 7.46
- Remarks on result:
- other: estimated
- Conclusions:
- Due to the uncertainty of the experimental results the Log Pow was calculated using Estimation Program Interface EPI ver. 4.1.
The calculated value for log Pow was 7.46 - Executive summary:
Due to the uncertainty of the experimental results the Log Powwas calculated using Estimation Program Interface EPI ver. 4.1.
The calculated value for log Powwas 7.46- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 6 March to 26 June 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
- Version / remarks:
- 11 July 2006
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- slow-stirring method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Name:
CAS No.: Oleyl Lactate (Dermol OL)
42175-36-0 (formally known as)
EC NO:
Chemical Name
Physical state: 946-088-2 (assigned since pre-registration)
Reaction Products of (Z)-octadec-9-enol and lactic acid
Clear yellow liquid
Sponsor lot number: P7610
Purity: 100%
Molecular weight: 340.5405 g/mol
Arrival date: 7 February 2018
Re-test date: 31 January 2020
Storage conditions: Room temperature (15 to 30°C) - Analytical method:
- other: SMV (PC) 3202072-01V.LogP.
- Type:
- log Pow
- Partition coefficient:
- 7.25
- Temp.:
- 25 °C
- Remarks on result:
- other: considered to be an estimate due to low water solublity of material
- Details on results:
- The partition coefficient by slow stir test was performed over a period of 167.17 hours, with 5 sampling time points taken. Due to the low water solubility, which was below the limit of quantification, but at or just above the limit of detection for the analytical method, the partition coefficient value determined experimentally should be considered to be an estimate. The estimated mean Log Pow (corrected for 1/variance) was 7.25 for the three sample vessels and there was no significant difference over five results for each of the vessels.
Due to the uncertainty of the experimental results the Log Pow was calculated using Estimation Program Interface EPI ver. 4.1. - Conclusions:
- The partition coefficient by slow stir test was performed over a period of 167.17 hours, with 5 sampling time points taken. Due to the low water solubility, which was below the limit of quantification, but at or just above the limit of detection for the analytical method, the partition coefficient value determined experimentally should be considered to be an estimate. The estimated mean Log Pow (corrected for 1/variance) was 7.25 for the three sample vessels and there was no significant difference over five results for each of the vessels.
Due to the uncertainty of the experimental results the Log Pow was calculated using Estimation Program Interface EPI ver. 4.1. - Executive summary:
The partition coefficient by slow stir test was performed over a period of 167.17 hours, with 5 sampling time points taken. Due to the low water solubility, which was below the limit of quantification, but at or just above the limit of detection for the analytical method, the partition coefficient value determined experimentally should be considered to be an estimate. The estimated mean Log Pow (corrected for 1/variance) was 7.25 for the three sample vessels and there was no significant difference over five results for each of the vessels.
Due to the uncertainty of the experimental results the Log Pow was calculated using Estimation Program Interface EPI ver. 4.1.
Referenceopen allclose all
Due to the uncertainty of the experimental results the Log Powwas calculated using Estimation Program Interface EPI ver. 4.1.
The calculated value for log Powwas 7.46
Description of key information
Study conducted to recognised testing guidelines [with GLP certification].
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 7.25
- at the temperature of:
- 20 °C
Additional information
Calculated Values
Due to the uncertainty of the experimental results due to poor water solubility the Log Powwas calculated using Estimation Program Interface EPI ver. 4.1.
The calculated value for log Powwas 7.46.
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