Phenol, 4,4'-(1-methylethylidene)bis-, oligomer with (chloromethyl)oxirane and ethylenediamine, reaction products with carbon disulphide, potassium salts

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

48 hours. Reported 2004

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Justification for type of information:

Marine study on invertebrates following guidance. No confirmatory analysis, but substance is soluble and stable in water.
The product testeed was commercial grade and included solvents; these solvents are of low toxicity to aquaitc and marine organisms and are not considered to have affected the outcome of the results.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Version / remarks:

Marine species in sea water

GLP compliance:

yes

Specific details on test material used for the study:

Test material supplied to the laboratory as ca 50% commercial grade mixture in ethanediol and butanol with water.
The presence of these solvents were not considered to impact on the test result.

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

other aquatic crustacea: Acartia tonsa

Details on test organisms:

Age approx 23 days

Test type:

static

Water media type:

saltwater

Limit test:

no

Total exposure duration:

48 h

Test temperature:

ca 20 C

Dissolved oxygen:

Recorded > 4 mg/l

Salinity:

Synthetic seawater at ca 3.3% salinity

Nominal and measured concentrations:

Nominal 0, 1, 5, 25, 100 mg/l of ca 50% commercial grade material as received by the laboratory
Estimated 0, 0.5, 2.5, 12.5, 50 mg/l of actives

Reference substance (positive control):

yes

Remarks:

3,5-dichlorophenol, 1 mg/l

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

ca. 4.7 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

ca. 2.3 mg/L

Nominal / measured:

estimated

Conc. based on:

act. ingr.

Basis for effect:

mortality

Details on results:

EC50 calculated to be ca 2.3 mg/l for the active, based on ca 50% activity in the commercial grade product tested.
The presence of the solvents in the commercial material are not considered to have affected the outcome of the study

Validity criteria fulfilled:

yes

Conclusions:

EC50 calculated to be ca 2.3 mg/l for the active, based on ca 50% activity in the commercial grade product tested.
The presence of the solvents in the commercial material are not considered to have affected the outcome of the study

Description of key information

EC50 calculated to be ca 2.3 mg/l for the active, based on ca 50% activity in the commercial grade product tested.

The presence of the solvents in the commercial material are not considered to have affected the outcome of the study

Key value for chemical safety assessment

Marine water invertebrates

Marine water invertebrates

Effect concentration:

2.3 mg/L