Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
2-amino-5-chlorobenzophenone
EC Number:
211-949-7
EC Name:
2-amino-5-chlorobenzophenone
Cas Number:
719-59-5
Molecular formula:
C13H10ClNO
IUPAC Name:
(2-amino-5-chlorophenyl)(phenyl)methanone
Test material form:
solid: particulate/powder

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
yes
Details on test solutions:
The test item was not soluble in the test medium. A special solubilisation protocol was carried out before the experimentation, according to the OECD 23 guidance document. This method consisted in stirring each test item nominal concentrations in test medium during 24h, in the dark dans 20°C.

Test organisms

Test organisms (species):
Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)

Study design

Test type:
semi-static
Water media type:
other: test medium
Limit test:
no
Total exposure duration:
72 h

Test conditions

Test temperature:
22.5 - 23.3 °C
pH:
8.1
Nominal and measured concentrations:
Nominal test item loading rate : 0.1, 0.3, 1, 3.2, 10.2 mg/L
Test item at the strat : /, /, /, 3.19, 10.20 mg
Remarque : for technical feasability issues, both concentrations (1 and 1.8 mg/L) were diluted from the water accomodated fraction (WAF) 10.2 mg/L.

Results and discussion

Effect concentrationsopen allclose all
Key result
Duration:
72 h
Dose descriptor:
EL50
Effect conc.:
1.6 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat. (dissolved fraction)
Basis for effect:
growth rate
Key result
Duration:
72 h
Dose descriptor:
EL10
Effect conc.:
0.2 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat. (dissolved fraction)
Basis for effect:
growth rate
Key result
Duration:
72 h
Dose descriptor:
EL50
Effect conc.:
0.9 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat. (dissolved fraction)
Basis for effect:
other: yield inhibition
Key result
Duration:
72 h
Dose descriptor:
EL10
Effect conc.:
0.1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat. (dissolved fraction)
Basis for effect:
other: yield inhibition

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The toxicity to aquatic algae was determined according to OECD 201 guideline. The study shows the following results :
- EL50 - 72h - growth rate = 1.6 mg/L
- EL50 - 72h - yield inhibition = 0.9 mg/L
In regard with GHS criteria, the test substance could be considered as toxic for aquatic algae.
Executive summary:

The toxicity to aquatic algae was determined according to OECD 201 guideline. The study shows the following results :

- EL50 - 72h - growth rate = 1.6 mg/L

- EL50 - 72h - yield inhibition = 0.9 mg/L

In regard with GHS criteria, the test substance could be considered as toxic for aquatic algae.