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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1946
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: publication lacks methodological details, documentation of study design, species and material and methods not sufficient

Data source

Reference
Reference Type:
publication
Title:
BARBITURATE ANTAGONISM OF ISONIPECAINE CONVULSIONS AND ISONIPECAINE POTENTIATION OF BARBITURATE DEPRESSION
Author:
E. LEONG WAY
Year:
1946
Bibliographic source:
Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 265, 1946.

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Barbital sodium
EC Number:
205-613-9
EC Name:
Barbital sodium
Cas Number:
144-02-5
Molecular formula:
C8H11N2O3.Na
IUPAC Name:
sodium 5,5-diethyl-4,6-dioxo-1,4,5,6-tetrahydropyrimidin-2-olate
Test material form:
not specified
Specific details on test material used for the study:
no details given

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
The concentration of a given dose was adjusted so that each animal received not less than 0.2 cc. and not more than 0.6 cc. of a solution
of the drug in distilled water.
No. of animals per sex per dose:
From fifteen to fifty-eight animals were used for each determination. (Not further specified.)
Control animals:
not specified
Details on study design:
Studies on toxicity were made on white mice weighing approximately 20 grams. The intraperitoneal median lethal dose (LD5O) of barbital, phenobarbital, ainytal, pentobarbital, evipal and diphenylhydantoin (the sodium salts were used throughout) were determined. In administering each compound the concentration of a given dose was adjusted so that each animal received not less than 0.2 cc. and not more than 0.6 cc. of a solution.
of the drug in distilled water.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
620 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Executive summary:

Acute toxicity intraperitoneal in mouse was reported as LD50 620 mg/kg bw.