Registration Dossier
Registration Dossier
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EC number: 205-613-9 | CAS number: 144-02-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1946
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: publication lacks methodological details, documentation of study design, species and material and methods not sufficient
Data source
Reference
- Reference Type:
- publication
- Title:
- BARBITURATE ANTAGONISM OF ISONIPECAINE CONVULSIONS AND ISONIPECAINE POTENTIATION OF BARBITURATE DEPRESSION
- Author:
- E. LEONG WAY
- Year:
- 1 946
- Bibliographic source:
- Journal of Pharmacology and Experimental Therapeutics. Vol. 87, Pg. 265, 1946.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- Barbital sodium
- EC Number:
- 205-613-9
- EC Name:
- Barbital sodium
- Cas Number:
- 144-02-5
- Molecular formula:
- C8H11N2O3.Na
- IUPAC Name:
- sodium 5,5-diethyl-4,6-dioxo-1,4,5,6-tetrahydropyrimidin-2-olate
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- no details given
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- The concentration of a given dose was adjusted so that each animal received not less than 0.2 cc. and not more than 0.6 cc. of a solution
of the drug in distilled water. - No. of animals per sex per dose:
- From fifteen to fifty-eight animals were used for each determination. (Not further specified.)
- Control animals:
- not specified
- Details on study design:
- Studies on toxicity were made on white mice weighing approximately 20 grams. The intraperitoneal median lethal dose (LD5O) of barbital, phenobarbital, ainytal, pentobarbital, evipal and diphenylhydantoin (the sodium salts were used throughout) were determined. In administering each compound the concentration of a given dose was adjusted so that each animal received not less than 0.2 cc. and not more than 0.6 cc. of a solution.
of the drug in distilled water.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 620 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Executive summary:
Acute toxicity intraperitoneal in mouse was reported as LD50 620 mg/kg bw.
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