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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
no guideline available
Principles of method if other than guideline:
Method for investigation of soluble substances:
Equipment: Mastersizer 2000 Version 5.12G; S/N: MAL 101659, Method with dried substance
Vibraxer: 35 %, Pressure of dispersion: 1 bar, Range of measurement: 0.020 – 2000.000 µm
Analytical model: Universal, Evaluation theory: Fraunhofer
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Percentile:
D10
Mean:
6.515 µm
St. dev.:
0.124
Percentile:
D50
Mean:
30.422 µm
St. dev.:
0.426
Percentile:
D90
Mean:
113.984 µm
St. dev.:
2.508

The result of the Laser Diffraction investigation of barbital sodium #10006/1706B100 is the following particle size distribution (mean of 3 determinations):

d(0.1): 6.515 µm

d(0.5): 30.422 µm

d(0.9): 113.984 µm

D[4,3]: 47.717 µm (average diameter of the particle volumes).

Executive summary:

The result of the Laser Diffraction investigation of barbital sodium #10006/1706B100 is the following particle size distribution:

d(0.1): 6.515 µm,

d(0.5): 30.422 µm,

d(0.9): 113.984 µm,

D[4,3]: 47.717 µm (average diameter of the particle volumes).

Description of key information

The result of the Laser Diffraction investigation of barbital sodium is the following particle size distribution:

d(0.1): 6.515 µm,

d(0.5): 30.422 µm,

d(0.9): 113.984 µm,

D[4,3]: 47.717 µm (average diameter of the particle volumes).

Additional information