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Physical & Chemical properties

Density

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Reference
Endpoint:
density, other
Remarks:
density
Type of information:
other: Data published in protein biochemistry textbook
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Density data have been generated for various protein families. The data published in the cited book comes from 20 different protein families and they all have densities in the range from 1.33 g/mL to 1.42 g/mL. The density for the substance has not been determined, but since it is a protein it is expected, with very high reliability, to also have a density in this range.
Principles of method if other than guideline:
Determination of the sedimentation constant allows calculation of the density using the Svedberg equation. This has been performed in peer reviewed articles and summarised in Creighton "Proteins: structure and molecular properties" (1993).
Type of method:
other: Determination of the sedimentation constant allows calculation of the density using the Svedberg equation. This has been performed in peer reviewed articles and summarised in Creighton "Proteins: structure and molecular properties" (1993).
Key result
Type:
density
Density:
> 1.33 - < 1.42 g/cm³
Temp.:
20 °C
Remarks on result:
other: density range for 20 different proteins from different protein-families

Creighton reviews density data retrieved from structurally and functionally different proteins. They all have densities in the range between 1.33 and 1.42 g/mL. We ascertain that Penicillin Amidohydrolase also has a density in this range since it is a protein, even though not experimentally determined.

Conclusions:
The substance is a protein and therefore it can be assumed that this has density within the range 1.33 - 1.42 g/mL.
Executive summary:

Densities have been determined for a wide range of different proteins. This analysis showed that the density range is between 1.33 and 1.42 g/mL.

Since Penicillin Amidohydrolase is a protein, we conclude that this protein also has density within this range.

Description of key information

The densities have been determined for a wide range of different proteins. This analysis showed that the density range is between 1.33 to 1.42 g/mL. Since the test substance is a protein, it is assumed that it also has density within this range.

Key value for chemical safety assessment

Relative density at 20C:
1.37

Additional information

We report the average value of 1.37 g/mL as a representative value of the density. However, it should be noted that the uncertainty is expected to be in the order of +/- 0.05 g/mL.