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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07/01/2109-18/02/2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
no
Type of method:
column elution method
Water solubility:
0.001 mg/L
Conc. based on:
act. ingr. (dissolved fraction)
Remarks:
of 1-[2,4-bis(2-chlorophenyl)-5-(3,4-dimethoxyphenyl)imidazol-1-yl]-2,4-bis(2-chlorophenyl)-5-(3,4-dimethoxyphenyl)imidazole
Loading of aqueous phase:
12 mg/L
Incubation duration:
1 h
Temp.:
20 °C
pH:
7.7
Water solubility:
0.001 mg/L
Conc. based on:
act. ingr. (dissolved fraction)
Remarks:
of 2,4-bis(2-chlorophenyl)-1-[2-(2-chlorophenyl)-4,5-diphenylimidazol-1-yl]-5-(3,4-dimethoxyphenyl)imidazole
Loading of aqueous phase:
12 mg/L
Incubation duration:
1 h
Temp.:
20 °C
pH:
7.7
Water solubility:
0.003 mg/L
Conc. based on:
act. ingr. (dissolved fraction)
Remarks:
of 2-(2-chlorophenyl)-1-[2-(2-chlorophenyl)-4,5-diphenylimidazol-1-yl]-4,5-diphenylimidazole,
Loading of aqueous phase:
12 mg/L
Incubation duration:
1 h
Temp.:
20 °C
pH:
7.7
Key result
Water solubility:
ca. 0.002 mg/L
Conc. based on:
test mat. (total fraction)
Loading of aqueous phase:
12 mg/L
Incubation duration:
1 h
Temp.:
20 °C
pH:
ca. 7.7
Remarks on result:
other:
Remarks:
based on the weighted average of the results obtained for each component
Conclusions:
The the experimental water solubilities of the three main constituent of the reaction mass are:
- Compound 1 (1-[2,4-bis(2-chlorophenyl)-5-(3,4-dimethoxyphenyl)imidazol-1-yl]-2,4-bis(2-chlorophenyl)-5-(3,4-dimethoxyphenyl)imidazole), 0.0007±0.0005 mg/L corresponding to 8x10-10 M;
- Compound 2 (2,4-bis(2-chlorophenyl)-1-[2-(2-chlorophenyl)-4,5-diphenylimidazol-1-yl]-5-(3,4-dimethoxyphenyl)imidazole), 0.001±0.001 mg/L corresponding to 2x10-9 M;
- Compound 3 (2-(2-chlorophenyl)-1-[2-(2-chlorophenyl)-4,5-diphenylimidazol-1-yl]-4,5-diphenylimidazole), 0.003±0.004 mg/L corresponding to 4x10-9 M.

Overall, the substance have a water solubility, based on the weighted average of the results obtained, of 0.0023 mg/L

Description of key information

Overall, the substance have a water solubility, based on the weighted average of the results obtained, of 0.0023 mg/L

Key value for chemical safety assessment

Water solubility:
0.002 mg/L
at the temperature of:
20 °C

Additional information