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EC number: 232-556-7
CAS number: 9000-72-0
Extractives and their physically modified derivatives. It is a product which may contain resin acids and their esters, terpenes, and oxidation or polymerization products of these terpenes. (Styrax, Styracaceae).
Benzoin hypersoluble is tested for acute oral toxicity in a study
performed similar to OECD TG 401. Three rats [Crl:CD: (SD) BR] per sex,
per dose, were exposed to 2000 or 5000 mg/kg bw test substance via oral
gavage. After an observation period of 14 days animals were necropsied.
In this study one animal died in the 2000 mg/kg bw dose group on day 5
and two in the 5000 mg/kg bw dose group on day 2. Pilo-erection and
increased salivation were observed in all rats within five minutes of
dosing. Other clinical signs, apparent within four hours of dosing were
limited to rats at the higher dose level and included abnormal body
weight carriage (hunched posture), abnormal gait (waddling), lethary,
decreased respiratory rate, ptosis and pallor of the extremities.
Recovery of the majority of rats surviving treatment, as judged by
external appearance and behaviour, was complete on day 2 (2.0 g/kg) or
day 3 (5.0 g/kg). One male dosed at 2.0 g/kg developed pilo-erection,
lethargy, decreased respiratory rate, pallor of the extremities, ataxia,
and body tremors on day 3, Ptosis and prostration on day 4 and was found
dead on day 5. Bodyweight losses (≤ 30 g) were recorded for rats that
died. All surviving rats achieved anticipated bodyweight gains
throughout the study. Autopsy did not reveal abnormalities in any of the
exposed rats. The acute oral toxicity test showed a LD50 of > 5000 mg/kg
bw. Based on this result, the substance is considered to be not acute
toxic via the oral route.
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