Registration Dossier
Registration Dossier
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EC number: 915-932-1 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 Feb 2018 - 17 April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Reference Identification: KSS-FR; Reaction mass of dipotassium 3,3’-sulphonylbis(benzenesulphonate) and potassium 3- (phenylsulphonyl)benzenesulphonate
CAS# 63316-33-6 and CAS# 63316-43-8
EC# 915-932-1
Label Identification: Arichem, LLC; 187 Sloss Industries Road; Ariton, AL 36311 USA
Product Sample: Potassium Diphenylsulfone Sulfonate; (KSS-FR) Lot: 1801-08
Date & Quantity Received: 29 Jan 18; 108.4 g (GW)
Physical Description: White powder
Storage Conditions: Room temperature
Purity: 92.6% active ingredient - Analytical monitoring:
- no
- Remarks:
- Substance is a non-volatile solid and known to be stable in water at environmetal pH
- Vehicle:
- no
- Details on test solutions:
- 2.6 g of test item was dissolved in 24,000 mL of dilution water and mixed well for 15 minutes
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- Justification of Species: One of the species specified in the regulatory guidelines
Source: STILLMEADOW, Inc.
Age Range-finding: Juvenile (DOB: 14-16 Jan 18)
Age Limit Test: Juvenile (DOB:24-26 Jan 18)
Size Range-finding: 0.0731-0.1317 g (mean: 0.1048 g) and 1.7-2.2 mm (mean: 2.0 mm)
Size Limit Test: 0.0731-0.1163 g (mean: 0.0962 g) and 1.7-1.9 mm (mean: 1.8 mm)
Quantity Range-finding: 10 organisms per test concentration and control
Quantity Limit Test: 3 replicates of 10 organisms for test concentration and control
Selction: The organisms were randomized into containers containing the appropriate concentration of test item. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- None
- Hardness:
- 85 mg/L CaCO3
- Test temperature:
- Target: 23 +/- 2 deg. Celsius
Actual: 21 - 23 deg. Celsius - pH:
- Target: 7.4 - 7.6
Actual: 7.1 - 7.5 - Dissolved oxygen:
- Target: >60% saturation
Actual: 82 - 98% saturation - Conductivity:
- Actual: 361.8 - 380.5
- Nominal and measured concentrations:
- Range Finding: 0.1, 1, 10, 50 and 100 mg/L
Limit Test: 100 mg/L - Details on test conditions:
- Fish were fed daily until 48 hours before the test was started. Fish were not fed during the test.
16-hours light/8-hours dark cycle - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Temperature, pH, Dissolved Oxygen, and Conductivity were all maintained within the desired test parameters throughout the study.
- Sublethal observations / clinical signs:
Limit Test Mortality Results:
Conc.
(mg/L)
Replicate
Number of Surviving Organisms
Mortality
0 Hrs
6 Hrs
24 Hrs
48 Hrs
72 Hrs
96 Hrs
Control
A
10
10
10
10
10
10
0.00%
B
10
10
10
10
10
10
C
10
10
10
10
10
10
100
A
10
10
10
10
10
10
0.00%
B
10
10
10
10
10
10
C
10
10
10
10
10
10
Note: All organisms had no observable abnormalities unless otherwise indicated.
Conc. = Concentration; Hrs = Hours
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 was determined to be >100 mg/L
- Executive summary:
In a GLP guidline study conducted according to OECD 203, the substance was evaluated for toxicity to Pimephales promelas in a 96-hour static nonrenewal test at a limit dose of 100 mg/L. All fish survived the study and, thus, the LC50 was determined to be >100 mg/L. There was no observable abnormalities in any of the test groups during any point of the study.
Reference
Description of key information
In a GLP guidline study conducted according to OECD 203, the substance was evaluated for toxicity toPimephales promelasin a 96-hour static nonrenewal test at a limit dose of 100 mg/L. All fish survived the study and, thus, the LC50 was determined to be >100 mg/L. There was no observable abnormalities in any of the test groups during any point of the study.
Key value for chemical safety assessment
Additional information
LC50 >100 mg/L
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