Registration Dossier
Registration Dossier
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EC number: 812-958-4 | CAS number: 1078712-76-1
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 31, 2016 to July 25, 2016
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study not directly monitoried by sponsor
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 1078712-76-1
- Molecular formula:
- C23-27H49-59N (Substance is a UVCB)
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- no
- Details on preparation and application of test substrate:
- 555 mg of test subtance was mixed with 9.455g of industrial sand and stirred for 5 minutes by high speed blender and then mixed with 740g of artificial soil by three-dimensional motion mixer for 1 hour.
Test organisms
- Test organisms (species):
- Eisenia fetida
- Details on test organisms:
- 3 months old
Study design
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
Test conditions
- Test temperature:
- 20 +/-2 C
- pH:
- 7.3-7.6
- Moisture:
- 33.3-35.2% dry weight
- Details on test conditions:
- continuous light at 400-800 lux.
Results and discussion
Effect concentrations
- Key result
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- Cumulative mortality of control earthworms were 0, 0, 0, and 10% in the 4 replicates. Cumulative mortality of 4 treatment groups were 0, 0, 10, 10% at the end of the 14 day treatment.
- Results with reference substance (positive control):
- The 24-hour LC50 of chloroacetamide was .00206 mg/cm2, fulfilling the validity of the test.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
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