Registration Dossier
Registration Dossier
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EC number: 203-026-2 | CAS number: 102-36-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3,4-dichlorophenyl isocyanate
- EC Number:
- 203-026-2
- EC Name:
- 3,4-dichlorophenyl isocyanate
- Cas Number:
- 102-36-3
- Molecular formula:
- C7H3Cl2NO
- IUPAC Name:
- 1,2-dichloro-4-isocyanatobenzene
- Details on test material:
- content: 99.5 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 0, 91.7, 97.4, 150.7, 255.5, 452.3 mg/m³
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 0.338 mg/L air
- Exp. duration:
- 4 h
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 0.452 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- male:
control 0/0/10
91.7 mg/m³ 0/0/5
97.4 mg/m³ 0/5/5
150.7 mg/m³ 0/5/5
255.5 mg/m³ 0/5/5
452.3 mg/m³ 1/5/5
female:
control 0/0/10
91.7 mg/m³ 0/0/5
97.4 mg/m³ 0/5/5
150.7 mg/m³ 1/5/5
255.5 mg/m³ 2/5/5
452.3 mg/m³ 3/5/5 - Clinical signs:
- other: up to and including 91.7 mg/kg no symptoms, >= 97.4 mg/m³ laboured breathing, bloddy and serious effluent of nose, reduced motility, ruffled coat, cyanosis, tachypnoe
- Body weight:
- loss of body weight
- Gross pathology:
- up to and including 97.4 mg/m³ no significant pulmonary change.
Animals which died during post observation period: inflated lung, liver, spleen and kidneys were pale, bloody content of gastro-intestinal tract, reddened intestine mucosa, hydrothorax and edema of the lung. - Other findings:
- A pronounced irritational potential of the substance to the respiratory system was found.
Any other information on results incl. tables
no further data
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- LC50 (female) = 0.338 mg/L
LC50 (male) > 0.452 mg/L - Executive summary:
Rats were exposed nose/head to 0, 91.7, 97.4, 150.7, 255.5, 452.3 mg/m³ 3,4 -dichlorophenyl isocyanate during 4 h.
Animals treated with 91.7 mg/m³ showed no clinical symptoms and no significant pathological pulmonary change. Therefore 91 mg/m³ is considered as the NOAEL. A pronounced irritational potential of the substance to the respiratory system was found.
Conclusion
LC50 (female) = 0.338 mg/L
LC50 (male) > 0.452 mg/L
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