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EC number: 480-890-9
CAS number: 906532-68-1
Everzol Orange ED-G Crude was administered to five Wistar rats of each
sex by a single dermal application at 2000 mg/kg body weight for 24
hours. Animals were subjected to daily observations and weekly
determination of body weight. Macroscopic examination was performed
after terminal sacrifice (Day 15).
No mortality occurred.
Lethargy, hunched posture, uncoordinated movements, quick breathing,
labored respiration, piloerection, chromodacryorrhoea, ptosis and/or
hypothermia were shown by all animals between Days 1 and 3, and for one
male hunched posture was also noted on Day 11.
The treated skin area of all animals showed scales and/or scabs between
Days 4 and 15, and showed brown staining between Days 2 and 15. The
treated skin area of all animals showed scales and/or scabs between Days
4 and 15, and showed brown staining between Days 2 and 15. Due to
brown-red discolouration of the treated skin on Day 2, no scoring of the
treated skin area was possible on that observation day.
The body weight gain during the observation period was within the range
expected for rats used in this type of study.
No abnormalities were found at macroscopic post mortem examination of
the animals. The dermal LD5O value of Everzol Orange ED-G Crude in
Wistar rats was established to exceed 2000 mg/kg body weight.
Based on these results, Everzol Orange ED-G Crude does not have to be
classified and has no obligatory labelling requirement for acute dermal
toxicity according to the: - Globally Harmonized System of
Classification and Labelling of Chemicals (GHS) of the United Nations
(2007), - Regulation (EC) No 1272/2008 on classification, labelling and
packaging of substances and mixtures.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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