Registration Dossier
Registration Dossier
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EC number: 202-908-4 | CAS number: 101-02-0
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to guideline , undissolved test substance was observed
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: DIN 38412 Testverfahren mit Wasserorganismen (L15)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Triphenyl phosphite
- EC Number:
- 202-908-4
- EC Name:
- Triphenyl phosphite
- Cas Number:
- 101-02-0
- Molecular formula:
- C18H15O3P
- IUPAC Name:
- triphenyl phosphite
- Test material form:
- other: liquid
- Details on test material:
- No 87/172
Constituent 1
Test solutions
- Vehicle:
- no
- Details on test solutions:
test water: reconstituted freshwater according to DIN 38 412 part 11, draft 1981. Preparation from fully demineralised tap water, conductivity: max 10 micro MHO
PREPARATION OF THE TEST SUBSTANCE : THE PRODUCT WAS ADDED TO THE TEST WATER WITHOUT ANY PRETREATMENT ; SUBSEQUENTLY THE FISH WERE PLACED INTO THE AQUARIA .
Acid capacity: ca. 5.5mmol/L
Test water
reconstitueted freshwater according to DIN 38 412, part 11, Draft Sept.1981, preparation from fully demineralised tap water (Conductivity: Max 10 micro MHO
Resalting:
294 mg/L CaCl2 3 2H2O
123.3 mg/L MGSO4 3 7H2O
64.8mg/l NaHCO3
5.8 mg/L KCl
aeration with oil-free air
Test water ready for use:
total hardness: 2.5 mmol/L
Acid capacit: 0.8 mmol/L
ratio Ca/Mg Ions: 4:1
Ratio Na/K ions: 10:1
pH: ca. 7.8
volume of test water: 10l
Test organisms
- Test organisms (species):
- Leuciscus idus
- Details on test organisms:
- Breeder/supplier: Fischzucht Paul Eggers, 2354 Hohenwestedt, Germany
body length: 5.7 cm
body weight: 2.8g
Corpulence factor of the batch (K, is calculated from weight W8g) and length L (cm) measured from the tip of the mouth to the end of thetailfin according to the formula K=100xW/Lxx3
Housing:
flowthrough tank in tap water
Hardness 2.5mm0l/L, acid capacity 5.5mmol/L, oxygen content >60% of maximum saturation, pH ca. 8.0, 21°C
duration ca 3 weeks
medical treatment: 2x 0.05mg/L malachite green chloride, 1x 10mg/L tetracycline hydrochloride
diet: growing feed F/B 50, SSNIFF Spezialdiaeten GmbH, 4470 Soest, Germany
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 2.5mmol/ L
- Test temperature:
- 21°C
- pH:
- 7.8
- Dissolved oxygen:
- >60% of maximum saturation
- Salinity:
- RATIO CA/MG IONS 4:1
RATIO NA/K IONS 10:1 - Nominal and measured concentrations:
- REASONS FOR THE SELECTION OF THE CONCENTRATIONS :
BASED ON THE RESULTS OF A RANGE FINDING STUD Y (LC 50 AFTER 96 H : BETWEEN 10 AND 100 MG/L)
4 .64, 10 .0, 21 .5, 46 .4 AND 100 MG/L . - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass: 30cm x 22cm x 24 cm
- fill volume: 10L
- Aeration: slight, continuously with oil-free air
- No. of organisms per vessel: 10
- Biomass loading rate: 2.8g fish/ L test water
- Photoperiod: 16 hours light, 8 hours darkness
adaption to test water 3 days
withdrawal of food: 1 day
Duration of housing and adaption: ca 3 weeks
Mortality during the last 2 weeks of housing:0%
Mortality during the adaption period: 0%
determination of mortality and symptoms: 1h ,4h, 24h, 48h, 72h, 96h - Reference substance (positive control):
- yes
- Remarks:
- chloroacetamide
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 1 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Duration:
- 4 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 22 - < 46 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 22 - < 46 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 22 - < 46 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 22 - < 46 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- >= 46.4 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Details on results:
- undissolved test substance was visible on the bottom of the aquaria
no abnormalities were observed - Results with reference substance (positive control):
- LC50 (48h) 24mg/L (Sept 28, 1987), corresponds to the normal sensitivity
Applicant's summary and conclusion
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