Registration Dossier
Registration Dossier
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EC number: 202-908-4 | CAS number: 101-02-0
Endpoint summary
Administrative data
Description of key information
Several guideline studies on aquatic toxicity are available:
- fish (zebra fish): LC50 (96h) > 12 mg/L mean measured (> 100mg/L nominal), NOEC (96h) 2.5 mg/L mean measured (32 mg/L nominal), flow through system
- supporting: fish (golden orfe): LC50 (96h) 22 - 46 mg/L nominal, static system
- Daphnia: EC50 (48h) 0.94 mg/L mean measured, NOEC (48h) < 0.47 mg/L mean measured, static system
- algae: ErC50 (72h) 86 mg/L initial measured test concentration, NOErC (72h) 7.8mg/L initial measured test concentration
- activated sludge: EC50 (3h) > 100mg/L nominal
Toxic effects were observed in the studies with fish, Daphnia and algae. No toxic effects to bacteria were observed.
The tests with fish, algae and Daphnia were performed above the water solubility and the dispersant Tween 80 was used. Furthermore, precipitation was observed. Analytical measurements showed a significant decrease of test substance concentration during the test.
The water solubility of the substance is low (< 0.1mg/L) and the substance is readily biodegradable. Furthermore, the substance contains functional groups subject to hydrolysis. The potential hydrolysis products phenol is according to disseminated data classified as hazardous for the environment (Aquatic Chronic 2, disseminated dossier ECHA, accessed June 25, 2018: self classification). Phenol is readily biodegradable but shows adverse effects to aquatic organisms in acute and chronic studies (di
sseminated dossier ECHA, accessed June 25, 2018). It is unclear if the observed effects were caused by the test substance or its degradation products or if the observed effects were physical effects caused by undissolved particles.
Therefore, the results of the studies with CAS 101 -02 -0 are used as worst case to assess the hazard of the substance.
Additional information
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