Registration Dossier

Environmental fate & pathways

Hydrolysis

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Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is readily biodegradable
the study does not need to be conducted because the substance is highly insoluble in water
Justification for type of information:
According to Regulation (EC) No. 1907/2006, Column 2 of Annex VIII, hydrolysis testing does not need to be conducted if the substance is readily biodegradable or is highly insoluble in water.  An analogue substance has been determined to be readily biodegradable (i.e. 69% degradation in 29 days but failing the 10-day window, which does not apply to a UVCB); the substance is insoluble in water (i.e., 0.0661 mg/L at 25˚C). Therefore, hydrolysis testing is waived.  
Reason / purpose for cross-reference:
data waiving: supporting information
Reason / purpose for cross-reference:
data waiving: supporting information

Description of key information

According to Regulation (EC) No. 1907/2006, Column 2 of Annex VIII, hydrolysis testing does not need to be conducted if the substance is readily biodegradable or is highly insoluble in water.  An analogue substance has been determined to be readily biodegradable (i.e. 69% degradation in 29 days but failing the 10-day window, which does not apply to a UVCB); the substance is insoluble in water (i.e., 0.0661 mg/L at 25˚C). Therefore, hydrolysis testing is waived.  

Key value for chemical safety assessment

Additional information