4,4'-methylenebis(2,6-xylidine)

Density

Link to relevant study record(s)

Reference

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

December 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method and under GLP. No deviation was reported. Test substance is adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Version / remarks:

2012

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Version / remarks:

2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

GLP compliance programme (inspected on 13 and 14 October 2014 / signed on 08 April 2015)

Type of method:

pycnometer method

Key result

Type:

relative density

Density:

1.111 g/cm³

Temp.:

20 °C

Remarks on result:

other: unitless

Presentation of Results

Results of the single determinations with the respective error as well as the mean value and its standard deviation are presented in the following tables:

Table 4.4/1.- Results of Single Determinations

Determination	Density in g/cm^3	Error of Determ. in g/cm^3
1	0.9588	0.0002
2	1.1118	0.0005
3	1.1101	0.0003

As the third determination confirmed the result of the second determination, the result of the first determination was not used for the calculation of the mean value.

Table 4.4/2.- Results – Mean Values

Parameter	Value	Unit	Standard Deviation	Relative Standard Deviation
Volume of Pycnometer	25.59	cm^3	0.0050	0.02%
Density of Test Item	1.1109	g/cm^3	0.0012	0.10%
Density of Test Item	1110.9	kg/m^3	1.2	0.10%
Relative Density of Test Item	1.1109		0.0012	0.10%

Discussion

The density of the test item was calculated as1.1109 ± 0.0005 g/cm³at 20.0 ± 0.2°C, which is the mean of two values.As the third determination confirmed the result of the second determination, the result of the first determination was not used for the calculation of the mean value.

Precision of the value is given as maximal error of a single determination.

Standard deviation was 0.0012 g/cm³, showing very good correlation of the two determinations. Therefore, the study is considered valid.

Conclusions:

The density of the test item was calculated as 1.1109 ± 0.0005 g/cm3 at 20.0 ± 0.2°C and the relative density is determined as D20/20 = 1.1109
Denser than water.

Executive summary:

The density of the test substance was measured under GLP according OECD 109 / EU A3 guideline, using the pycnometer method.

3 determinations were performed. The result obtained was the mean of two determinations. As the third determination confirmed the result of the second determination, the result of the first determination was not used for the calculation of the mean value.

This result was then converted to relative density towards water at 20 °C.

Mean density: 1.1109 ± 0.0005 g/cm3 at 20.0 ± 0.2°C

Mean relative density (D20/20) : 1.1109

Description of key information

The density of the test item was calculated as 1.1109 ± 0.0005 g/cm3 at 20.0 ± 0.2°C and the relative density is determined as D20/20 = 1.1109

Denser than water.

Key value for chemical safety assessment

Relative density at 20C:

1.111

Additional information

A fully reliable experimental study, conducted under GLP according to OECD 109 /EU A3 guideline, using pycnometer method, is available. It is considered as a key study, and the result is retained as key data.