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Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 17, 2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Qualifier:
no guideline followed
Principles of method if other than guideline:
Laser light scattering. The test was performed according to the SOP - STR 071 Ed. 01 (Hydro 2000S-A) protocol.
The particle size distribution was analyzed using the Mastersizer 2000 tool, which uses the technique of laser diffraction to measure the size of particles. It measures the intensity of light scattered as a laser beam passes through a dispersed particulate sample. This data is then analyzed to calculate the size of the particles that created the scattering pattern.
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution
Percentile:
D10
Mean:
ca. 9.455 µm
Remarks on result:
other: after 2 minutes of ultrasonic treatement
Percentile:
D50
Mean:
ca. 59.509 µm
Remarks on result:
other: after 2 minutes of ultrasonic treatement
Percentile:
D90
Mean:
ca. 209.972 µm
Remarks on result:
other: after 2 minutes of ultrasonic treatement

The analysis has been run after 2 minutes of sonification.

Conclusions:
MD10 = 9.455 µm
MD50 = 59.509 µm
MD90 = 209.972 µm
Executive summary:

Method:


The substance has been tested for granulometry by the volumetric distribution. 


The particle size distribution was analyzed using the Mastersizer 2000 tool, which uses the technique of laser diffraction to measure the size of particles. It measures the intensity of light scattered as a laser beam passes through a dispersed particulate sample. This data is then analyzed to calculate the size of the particles that created the scattering pattern.


 


Result:


MD10 = 9.455 µm


MD50 = 59.509 µm


MD90 = 209.972 µm

Description of key information

MD10 = 9.455 µm


MD50 = 59.509 µm


MD90 = 209.972 µm

Additional information

Laser light scattering