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Hydrolysis

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical (+)-Neomenthol can be expected to be 7.3 yrs and 270 days at pH 7 and 8, respectively with a hydrolysis rate constant of 0.03 L/mol-sec. Thus, based on this half-life value, it can be concluded that the test chemical (+)-Neomenthol is not hydrolysable.

Additional information

Hydrolysis

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical (+)-Neomenthol (CAS no. 2216 -52 -6). The studies are as mentioned below:

The half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant was determined to be 0.03L/mol-sec with a corresponding half-lives of 7.3 yrs and 270 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

In an another study, the half-life of the test chemical was determined in water. Although the half-life value of test chemical was not known, but it was noted that the test chemical does not react with water and the only functional other than carbon-carbon and carbon-hydrogen bonds is the hydroxyl group, which does not hydrolyze. Thus, based on this, test substance was reported to be hydrolytically stable and thus can be considered to be not hydrolysable.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical (+)-Neomenthol can be expected to be 7.3 yrs and 270 days at pH 7 and 8, respectively with a hydrolysis rate constant of 0.03 L/mol-sec.Thus, based on this half-life value, it can be concluded that the test chemical (+)-Neomenthol is not hydrolysable.