Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-691-4 | CAS number: 2216-52-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication.
Data source
Reference
- Reference Type:
- publication
- Title:
- Neomenthol
- Author:
- World Health Organization
- Year:
- 1 999
- Bibliographic source:
- World Health Organization
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity of (+)-Neomenthol (CAS no: 2216-52-6) in mice.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- (+)-neomenthol
- EC Number:
- 218-691-4
- EC Name:
- (+)-neomenthol
- Cas Number:
- 2216-52-6
- Molecular formula:
- C10H20O
- IUPAC Name:
- (1S,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol
- Details on test material:
- - IUPAC Name: (+)-Neomenthol- InChI: 1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9) 11/h7-11H,4-6H2,1-3H3/t8-,9+,10+/m1/s1- Smiles: C[C@@H]1CC[C@H]([C@H](C1)O)C(C)C- Name of test material (as cited in study report):d-Neomenthol- Molecular formula :C10H20O- Molecular weight:156.267 g/mol- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- - IUPAC Name: (+)-Neomenthol- InChI: 1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9) 11/h7-11H,4-6H2,1-3H3/t8-,9+,10+/m1/s1- Smiles: C[C@@H]1CC[C@H]([C@H](C1)O)C(C)C- Name of test material (as cited in study report):d-Neomenthol- Molecular formula :C10H20O- Molecular weight:156.267 g/mol- Substance type:Organic
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 4000 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed in treated mice.
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral LD50 value was considered to be 4000 mg/kg bw, when mice were treated with (+)-Neomenthol (CAS no: 2216-52-6) via oral route.
- Executive summary:
Acute oral toxicity study of (+)-Neomenthol (CAS no: 2216-52-6) was conducted in mice at the dose concentration of 4000 mg/kg bw. 50% mortality was observed in treated mice. Hence, LD50 value was considered to be 4000 mg/kg bw, when mice were treated with(+)-Neomentholvia oral route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
