Registration Dossier
Registration Dossier
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EC number: 904-139-6 | CAS number: -
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Safety evaluation of diethyl citrate and its impact on vascular calcification
- Author:
- Duan C-Y, Huang L-H, Guo D, Ouyang J-M, Han J and Gui B-S
- Year:
- 2 017
- Bibliographic source:
- Advances in Biological Sciences Research, Vol. 6, pages 62-67
Materials and methods
Test guideline
- Guideline:
- other: Up and down procedure
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Reaction mass of diethyl hydrogen 2-hydroxypropane-1,2,3-tricarboxylate and ethyl dihydrogen 2-hydroxypropane-1,2,3-tricarboxylate and triethyl citrate
- EC Number:
- 904-139-6
- Cas Number:
- 172820-60-9
- Molecular formula:
- not applicable, multi constituent substance
- IUPAC Name:
- Reaction mass of diethyl hydrogen 2-hydroxypropane-1,2,3-tricarboxylate and ethyl dihydrogen 2-hydroxypropane-1,2,3-tricarboxylate and triethyl citrate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: physiological saline
- Doses:
- 7
- No. of animals per sex per dose:
- 1
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LC0
- Effect level:
- <= 9 900 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- Activity of the mice was not significantly reduced and no death occurred at dose levels of less than 6900 mg/kg body weight. At dose levels up to 9900 mg/kg, reduced activity, ataxia, slow and sluggish movement immediately occurred. Recovery occurred within 1 hour of dosing and no deaths occurred.
- Body weight:
- No effects
- Gross pathology:
- No significant lesions of the body tissues and organs were observed.
Applicant's summary and conclusion
- Executive summary:
Administration of a single dose of diethyl citrate to the mouse by intraperitoneal administration resulted in no mortality at dose levels up to 9900 mg/kg body weight.
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