Registration Dossier
Registration Dossier
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EC number: 250-001-7 | CAS number: 30007-47-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-06-27 to 2016-06-30
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004-04-13
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Mr. Klemmt; E-EMD/QR - J55, Batch identification: A14-Q0201
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: ambient temperature - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.6
- Temp.:
- 23 °C
- pH:
- 6.1
- Details on results:
- Additionally the solubility of the test item in n-octanol was visually tested. The solubility of the test item in n-octanol was > 10.46 g/L < 58.76 g/L.
Reference
Component |
tR [min] (mean value out of two determinations) |
|
log k´ |
log Pow |
Formamide |
1.6 |
|
|
|
2-Butanone |
3.8 |
1.39 |
0.142 |
0.3 |
| Acetanilide | 5.8 | 2.62 | 0.418 | 1.0 |
| 4-Methylbenzylalcohol | 10.8 | 5.70 | 0.756 | 1.6 |
| Acetophenone | 17.7 |
10.04 | 1.002 | 1.7 |
| Benzonitrile | 19.9 | 11.41 | 1.057 | 1.6 |
| Nitrobenzene | 32.5 | 19.20 | 1.283 | 1.9 |
| Methylbenzoate | 40.1 | 23.97 | 1.380 | 2.1 |
| Test item | 15.7 | 8.78 | 0.943 | 1.6 |
Equation: log Pow = 1.3021 log k' + 0.3342
Description of key information
In a GLP-study according to OECD Guideline 117 the partition coefficient of the test substance was determined at logPow = 1.6 at 23 °C at pH 6.1. The value was calculated based on HPLC measurement data.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.6
- at the temperature of:
- 23 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
