Registration Dossier
Registration Dossier
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EC number: 250-001-7 | CAS number: 30007-47-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1972-08-07
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP and non-guideline compliant study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
- Reference Type:
- publication
- Title:
- Bronidox, a new preserving agent for the cosmetics: properties and toxicological-dermatological assays
- Author:
- M. Potokar, et al.
- Year:
- 1 976
- Bibliographic source:
- Fette, Seifen, Anstrichmittel, Jahrgang 78, Nr. 7, 269-276
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 977
- Reference Type:
- publication
- Title:
- Final Report on the Safety Assessment of 5-Bromo-5-Nitro-1,3-Dioxane
- Author:
- Anonymous (Cosmetic Ingredient Review 10)
- Year:
- 1 990
- Bibliographic source:
- Journal of the American College of Toxicology, Volume 9, Number 2
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 5-bromo-5-nitro-1,3-dioxane
- EC Number:
- 250-001-7
- EC Name:
- 5-bromo-5-nitro-1,3-dioxane
- Cas Number:
- 30007-47-7
- Molecular formula:
- C4H6BrNO4
- IUPAC Name:
- 5-bromo-5-nitro-1,3-dioxane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 157 g (mean value)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- olive oil
- Remarks:
- heated
- Details on exposure:
- Injection volume: 20 mL/kg
- Doses:
- 10, 15.8, 19.9, 25.1, 31.6, 39.8, 50.1, 100 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Examinations performed: clinical signs
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 31.5 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 10 mg/kg: 0/ 10
15.8 mg/kg: 0/ 10
19.9 mg/kg: 1/ 10
25.1 mg/kg: 4/ 10
31.6 mg/kg: 6/ 10
39.8 mg/kg: 7/ 10
50.1 mg/kg: 8/ 10
100 mg/kg: 10/ 10
Mortality was oberserved after 4 hours - 6 days - Clinical signs:
- Observation at 10 mg/kg bw and above:
Decreased and accelerated breathing, staggering, after 2 days extreme nerve symptoms (agitation, shaking, rotation movement) - Body weight:
- Not examined
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
