Bis(2,4,5-trichloro-6-carbopentoxyphenyl) oxalate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1999

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

The day prior to application of test article, the fur was removed from the dorsal area of the trunk of each rabbit, being careful to avoid abrading the skin. The test article was administered on the clipped dorsal trunk of each animal on Day 1 at 2000 mg/kg based upon the initial body weight. The specific gravity of the test article is 1.07 g/ml. The exposure time was 24 hours.

The test substance was applied to a small area of skin and covered with a gauze patch. The patch was held in contact with the skin with a sheet of rubber dam. The trunk of the animal was wrapped with an elastic bandage dressing which was held in place with non-irritating tape for the duration of the exposure period. Access by the animal to the patch and resultant ingestion\inhalation of the test substance was prevented.

At the end of the exposure period, residual test article was removed using water and gauze without altering the existing response or the integrity of the epidermis. Each site was unwrapped and scored.

GLP compliance:

yes

Test type:

fixed dose procedure

Test material

Test material information

Constituent 1

Reference substance name:

Bis(2,4,5-trichloro-6-carbopentoxyphenyl) oxalate

EC Number:

250-195-3

EC Name:

Bis(2,4,5-trichloro-6-carbopentoxyphenyl) oxalate

Cas Number:

30431-54-0

Molecular formula:

C26H24Cl6O8

IUPAC Name:

pentyl 2,3,5-trichloro-6-[(2-oxo-2-{3,4,6-trichloro-2-[(pentyloxy)carbonyl]phenoxy}acetyl)oxy]benzoate

Constituent 2

Reference substance name:

Butyl benzoate

EC Number:

205-252-7

EC Name:

Butyl benzoate

Cas Number:

136-60-7

Molecular formula:

C11H14O2

IUPAC Name:

butyl benzoate

Test material form:

liquid

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

24 h

Doses:

2000 mg/kg

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

No deaths occurred in the animals receiving a single topical dose of 2000 mg/kg.

Clinical signs:

other: No clinical signs were observed. Erythema, edema, necrosis, fissuring, sloughing, and flaking of the skin at the application site was observed.

Other findings:

No visible lesions were observed in any of the animals at terminal necropsy.