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EC number: 277-923-2 | CAS number: 74563-64-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The toxicity to aquatic algae was assessed according to the OECD Test Guideline 201, and EU Method C.3. The EC50 values, based on the time-weighted mean measured test concentrations were > 0.11 mg/L. NOEC was determined to be 0.11 mg/L.
This study showed that there were no toxic effects at saturation.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.11 mg/L
- EC10 or NOEC for freshwater algae:
- 0.11 mg/L
Additional information
The toxicity to aquatic algae was assessed according to the OECD Guidelines for Testing of Chemicals (2006) No 201, "Freshwater Alga and Cyanobacteria, Growth Inhibition Test" referenced as Method C.3 of Commission Regulation (EC) No 761/2009.
Preliminary solubility work conducted indicated that it was not possible to obtain a testable solution of the test item using traditional methods of preparation e.g. ultrasonication and high shear mixing.
A preliminary media preparation trial indicated that a dissolved test item concentration of approximately 0.50 mg/L was obtained from a saturated solution method of preparation indicating this to be the limit of water solubility of this item under test conditions.
Analysis of the 100% v/v saturated solution test preparations at 0, 24, 48 and 72 hours showed measured test concentrations of 0.17, 0.16, 0.11 and less than the limit of quantification (LOQ) of the analytical method employed, determined to be 0.026 mg/L, were obtained respectively.
Given this decline in measured test concentrations it was considered appropriate to calculate the results based on the time-weighted mean measured test concentration only in order to give a “worst case” analysis of the data.
The EC50 values, based on the time-weighted mean measured test concentrations were > 0.11 mg/L. NOEC was determined to be 0.11 mg/L.
This study showed that there were no toxic effects at saturation.
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