Registration Dossier
Registration Dossier
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EC number: 242-285-6 | CAS number: 18406-41-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See attached justification
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 12.01.2018 - 09.02.2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- 0 (start of exposure), 48 and 72 hours (end of the exposure)
- Vehicle:
- no
- Test organisms (species):
- Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- Origin: Pflanzenphysiologisches Institut der Universität Göttingen Nikolausberger Weg 18, D-37073 Göttingen
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Hardness:
- 23.0 mg CaCO3/L
- Test temperature:
- 22.8 °C (mean)
- pH:
- 7-60 - 9.19
- Conductivity:
- 143 µS/cm
- Nominal and measured concentrations:
- Nominal Loadings (mg/L): 10, 31.6, 100, 316, 1000, control
Measured concentration at 0 hours (mg/L): 0.904, 3.98, 17.2, 43.6, 84.7
Measured concentations at 72 hours (mg/L): < LOQ,- Key result
- Duration:
- 72 h
- Dose descriptor:
- EL50
- Effect conc.:
- 671 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EL10
- Effect conc.:
- 102 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
Data source
Materials and methods
Test material
- Reference substance name:
- 3,3,6,6-tetramethoxy-2,7-dioxa-3,6-disilaoctane
- EC Number:
- 242-285-6
- EC Name:
- 3,3,6,6-tetramethoxy-2,7-dioxa-3,6-disilaoctane
- Cas Number:
- 18406-41-2
- Molecular formula:
- C8H22O6Si2
- IUPAC Name:
- 3,3,6,6-tetramethoxy-2,7-dioxa-3,6-disilaoctane
Constituent 1
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EL50
- Effect conc.:
- 671 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EL10
- Effect conc.:
- 102 mg/L
- Nominal / measured:
- meas. (initial)
- Basis for effect:
- growth rate
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
