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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
See attached justification
Cross-reference
Reason / purpose for cross-reference:
read-across source
Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
02.02.2018 - 15.02.2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
GLP compliance:
yes (incl. QA statement)
Analytical monitoring:
yes
Details on sampling:
At the start of the exposure and at renewal (0 and 24 hours), samples were taken after preparation of the test item concentrations and analyzed. At renewal and at the end of the exposure (24 and 48 hours), samples of the 24-hours old media were taken from the vessels.
Vehicle:
no
Test organisms (species):
Daphnia magna
Details on test organisms:
Origin: Institut Dr. Nowak
Breeder: Noack laboratorien GmbH, Käthe-Paulus-Str. 1, 31157, Sarstedt, Germany
Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Hardness:
262 mg CaCo3/L
Test temperature:
18 - 22 °C
pH:
7.42 - 7.52
Dissolved oxygen:
4.49 - 6.87 mg/L
Nominal and measured concentrations:
Nominal loading levels (mg/L): 316, 100, 31.6, 10.0, 3.16, control
Measured concentrations at the start of exposure (0 h) (mg/L): 193, 50.9, 20.7, 3.69 1.33
Measured concentrations at renewal (24 h) (mg/L): 71.9, 52.8, 12.9, 4.62, 1.65
Key result
Duration:
48 h
Dose descriptor:
EL50
Effect conc.:
92.2 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EL10
Effect conc.:
83.2 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
EL100
Effect conc.:
316 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Validity criteria fulfilled:
yes

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3,6,6-tetramethoxy-2,7-dioxa-3,6-disilaoctane
EC Number:
242-285-6
EC Name:
3,3,6,6-tetramethoxy-2,7-dioxa-3,6-disilaoctane
Cas Number:
18406-41-2
Molecular formula:
C8H22O6Si2
IUPAC Name:
3,3,6,6-tetramethoxy-2,7-dioxa-3,6-disilaoctane

Results and discussion

Effect concentrations
Key result
Duration:
48 h
Dose descriptor:
EL50
Effect conc.:
92.2 mg/L
Nominal / measured:
nominal
Basis for effect:
mobility

Applicant's summary and conclusion