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Density

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Reference
Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18-21 September 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Version / remarks:
2012
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.3 (Relative Density)
Version / remarks:
2008
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
Remarks:
inspected on 15 and 16 November 2017 / signed on 15 May 2018
Type of method:
pycnometer method
Remarks:
with a replacement liquid
Key result
Type:
relative density
Density:
1.24 other: unitless
Temp.:
20 °C
Key result
Type:
density
Density:
1.24 g/cm³
Temp.:
20 °C

Table 4.4/1: Measured Values

 

First Determination

Error rel.

Error abs.

Temperature

20.1

°C

 

 

0.1

Density of water

0.998203

g/cm3

 

2.00%

0.0002

Weighing #

m1

m2

m3

m4

m5

Item

Pycn. empty

Pycn. + H2O

Pycn. +

repl.liq.

Pycn. + test

item

Pycn. + test

item + repl. liq.

Mass in g

36.2278

61.7828

56.3605

42.7062

58.7234

Temperature in °C

20.2

20.1

20.2

20.2

20.0

Volume of Pycnometer

25.6010

cm3

 

 

 

Density of Replacement Liquid

0.7864

 g/cm3

 

Error rel.

Error abs.

Density of Test Item

1.2379

g/cm3

 

0.0437%

0.0005

Second Determination

Error rel.

Error abs.

Temperature

20.0

°C

 

 

0.1

Density of water

0.998203

g/cm3

 

2.00%

0.0002

Weighing #

m1

m2

m3

m4

m5

Item

Pycn. empty

Pycn. + H2O

Pycn. +

repl.liq.

Pycn. + test

item

Pycn. + test

item + repl. liq.

Mass in g

36.2276

61.7790

56.3585

43.0830

58.769

Temperature in °C

20.0

20.0

20.1

20.2

20.2

Volume of Pycnometer

25.5974

cm3

 

 

 

Density of Replacement Liquid

0.7864

g/cm3

 

Error rel.

Error abs.

Density of Test Item

1.2431

g/cm3

 

0.0417%

0.0005

Results of the single determinations with the respective error as well as the mean value and its standard deviation are presented in the following tables:

Table 4.4/2: Results of Single Determinations

 

Determination

Density in g/cm3

Error of Determ. in g/cm3

1

1.2379

0.0005

2

1.2431

0.0005

 

Table 4.4/3 Results – Mean Values

 

Parameter

Value

Unit

Standard

Deviation

Relative Standard

Deviation

Volume of Pycnometer

25.60

cm3

0.0026

0.01%

Density of Test Item

1.2405

g/ cm3

0.0037

0.30%

Density of Test Item

1240.5

Kg/m3

3.7

0.30%

Relative Density of Test Item (D20/4)

1.2405

 

0.0037

0.30%

The relative density of the test item has the same number value, but no unit, assuming that relative density is given as the ratio of test item density to density of water at 4°C, having a standard density of 0.999975 g/cm3 (source: CRC Handbook of Chemistry and Physics - 90th edition / Section 6 - Fluid properties - p.6 -7).

The density of the test item was calculated as 1.2405 ± 0.0005 g/cm3 at 20.0 ± 0.2 °C, which is the mean of two independent determinations ± the standard deviation. Standard deviation shows good correlation of the two determinations. Therefore, the study is considered valid.

Conclusions:
The density of the test substance was calculated as 1.2405 ± 0.0005 g/cm3 at 20.0 ± 0.2 °C and the relative density was determined as D20/4 = 1.2405
Denser than water
Executive summary:

The density of the test substance was measured under GLP according OECD 109 / EU A3 guideline, using the pycnometer method (with a replacement liquid).

Two determinations were performed and the mean value was retained.

This result was then converted to relative density.

Mean density: 1.2405 g/cm3at 20.0 ± 0.2 °C

Mean relative density (D20/4) : 1.2405

Description of key information

The density of the test item was measured as 1.2405 ± 0.0005 g/cm3 at 20.0 ± 0.2 °C.

D20/4 = 1.2405

Key value for chemical safety assessment

Relative density at 20C:
1.24

Additional information

A fully reliable experimental study, conducted under GLP according to OECD 109 /EU A3 guideline, using pycnometer method with a replacement liquid, is available. It is considered as a key study, and the result is retained as key data.