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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 406 (Skin Sensitisation)
GLP compliance:
no
Type of study:
Buehler test
Justification for non-LLNA method:
this study report was performed in 2003

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
male/female

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
epicutaneous, semiocclusive
Vehicle:
vegetable oil
Concentration / amount:
1g/mL
Challengeopen allclose all
Route:
epicutaneous, semiocclusive
Vehicle:
vegetable oil
Concentration / amount:
1g/mL
No. of animals per dose:
15

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
1st reading
Hours after challenge:
24
Group:
negative control
Dose level:
0.2ml
No. with + reactions:
0
Total no. in group:
15
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 0.2ml. No with. + reactions: 0.0. Total no. in groups: 15.0.
Reading:
1st reading
Hours after challenge:
24
Group:
test group
Dose level:
0.2mL
No. with + reactions:
0
Total no. in group:
15
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 0.2mL. No with. + reactions: 0.0. Total no. in groups: 15.0.
Reading:
1st reading
Hours after challenge:
24
Group:
positive control
Dose level:
1% DNCB 0.2mL
No. with + reactions:
13
Total no. in group:
15
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 24.0. Group: positive control. Dose level: 1% DNCB 0.2mL. No with. + reactions: 13.0. Total no. in groups: 15.0.

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information