Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982

Materials and methods

Principles of method if other than guideline:
The precise methodology for exposure and measurement of bornan-2-one has been described in Camphor Poisoning Abuse of Camphor as a Stimulant
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline

Test animals

Species:
human
Sex:
male

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
unchanged (no vehicle)
Doses / concentrations
Remarks:
Doses / Concentrations:
6-10g

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
The plasma protein binding was determined by ultrafiltration with Zentriflow membranes of Amicon Inc. (Ryan and Hanna 1971; Vohland and Streichert 1978). A correction had to be made for the adsorption of camphor at the membrane. The protein binding was 61±6% at a concentration of 10 μg camphor/ml plasma.

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Metabolite Ret. time ((min: sec)) Mass fragments m/e (intensity %)
I 5-hydroxycamphor 5 : 34 M + 168 (48), 153 (29), 135 (6), 125 (48), 111(100), 109 (31)
II 5-ketocamphor 3 : 10 M + 166 (96), 151 (14), 138 (12), 109 (79), 95(48), 69 (100)
III 9-hydroxycamphor 7 : 51 M + 168 (19), 153 (38), 135 (7), 125 (13), 111(28), 109 (31), 108 (100), 107 (53)
IV 8-hydroxycamphor 6 : 50 M + 168 (19), 153 (4), 137 (15), 109 (18), 108(53), 95 (100)
V 3-hydroxycamphor 4 : 55 M + 168 (9), 153 (91), 135 (13), 108 (93), 107(100), 93 (60)
VI 8 or 9-camphor carbonic acidtrimethylsilylester 7 : 17 M + 254 (6), 239 (8), 226 (4), 225 (4), 108 (58), 93(19), 73 (100)
VII Isoborneole 1 : 10 M + 154 (1), 139 (8), 136 (6), 121 (7), 110 (20), 95(100), 93 (11)










Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results