Registration Dossier
Registration Dossier
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EC number: 227-842-3 | CAS number: 6000-44-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Main parameters measured are comparable to guideline study, GLP status unknown, otherwise acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Salmonella Mutagenicity Test Results for 250 Chemicals
- Author:
- Steve Haworth, Timothy Lawlor, Kristien Mortelmans, William Speck,
and Errol Zeiger - Year:
- 1 983
- Bibliographic source:
- Literature
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 476 (In Vitro Mammalian Cell Gene Mutation Test)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Glycine
- EC Number:
- 200-272-2
- EC Name:
- Glycine
- Cas Number:
- 56-40-6
- Molecular formula:
- C2H5NO2
Constituent 1
- Specific details on test material used for the study:
- Glycine (CAS 56-40-6) purchased from Aldrich (LOT LC 081387)
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
Controlsopen allclose all
- Untreated negative controls:
- yes
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- sodium azide
- other: 4-nitro-o-phenylenediamine;
Results and discussion
Test results
- Key result
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Negative with metabolic activation
Negative without metabolic activation - Executive summary:
Glycine was not mutagenic.
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