4-(5-Ethyl-tetrahydropyran-2-yl)-phenol

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

20.06. - 06.12.16

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point/Boiling Range)

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

GLP compliance:

no

Type of method:

differential scanning calorimetry

Key result

Boiling pt.:

> 240 - < 430 °C

Atm. press.:

1 013.3 hPa

Decomposition:

yes

One DSC measurement in an aluminium crucible with a hole showed an endothermal effect after the melting in the temperature range of 240 - 430 °C. No further endothermal or exothermal effects were observed up to the final temperature (500 °C). The mass loss after the DSC measurements amounted to 94 %.

 

Table 1: Boiling Point (DSC measurement).

Ident No.	Test item /mg	Starting temperature / °C	Final test temperature / °C	Temperature range (boiling) / °C	Onset / °C	Crucible	Observations after the measurement
35624	8.09	25	500	240 - 430	-	Aluminium with a hole	Slightly black test item discharged out of the crucible

 

A measurement with the capillary method was performed to clarify the results of the DSC measurements. Since this measurement was performed only as a verifying screening a high heating rate of 10 K/min was chosen and therefore the absolute temperature values derived with the capillary method are not as accurate as the DSC results. The filling height of the test item was approximately 5 mm.

 

Table 2: Results of the capillary method

No.	Set point/°C	Heating rate/ K/min	Endpoint/ °C	Remarks
1	220	10	410	(Test item is a white powder at ambient temperature) Approx. 220 °C: test item appeared melted Approx. 279 °C: beginning formation of bubbles Approx. 310 °C: formation of bubbles continued, test item discoloured to yellow Approx. 338 °C: increasing formation of bubbles, test item discoloured to amber Approx. 372 °C: ongoing formation of bubbles, test item discoloured to dark orange Approx. 401 °C: test item boiled Approx. 410 °C: test item boiling ongoing, end of test, test item discoloured to dark brown

 

Under consideration of the results from the thermal stability, the DSC measurements and the capillary method it was concluded that the test item boiled under decomposition within a temperature range of 240 - 430 °C.

Conclusions:

The test item boiled under decomposition within a temperature range of 240 - 430°C under atmospheric conditions.

Executive summary:

A study was conducted according to OECD test guideline 103 and Regulation (EC) No 440/2008 method A.2 to determine the boiling point of the test item using differential scanning calorimetry. The test item and the reference are heated up from the starting temperature to the final temperature at a constant heating rate in a defined atmosphere (nitrogen). Open crucibles are used as containers for the test item and as empty reference crucible. The quantity of heat absorbed or released is measured and recorded.

Under consideration of the results from the thermal stability, the DSC measurements and the capillary method it was concluded that the test item boiled under decomposition within a temperature range of 240 - 430 °C.

Description of key information

A study was conducted according to OECD test guideline 103 and Regulation (EC) No 440/2008 method A.2 to determine the boiling point of the test item using differential scanning calorimetry. The test item and the reference are heated up from the starting temperature to the final temperature at a constant heating rate in a defined atmosphere (nitrogen). Open crucibles are used as containers for the test item and as empty reference crucible. The quantity of heat absorbed or released is measured and recorded.

Under consideration of the results from the thermal stability, the DSC measurements and the capillary method it was concluded that the test item boiled under decomposition within a temperature range of 240 - 430 °C.