4-(5-Ethyl-tetrahydropyran-2-yl)-phenol

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

20.06. - 06.12.06

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

GLP compliance:

no

Type of method:

differential scanning calorimetry

Key result

Melting / freezing pt.:

> 87 - < 90 °C

Atm. press.:

1 013.3 hPa

Decomposition:

no

Sublimation:

no

Two DSC measurements with a heating range of 10 K/min showed an endothermal effect (melting in the temperature range of 60 - 105 °C with onset temperatures of 87.08 °C and 89.11 °C, respectively. The onset temperature (see Table 1) was derived from the intersection of the tangent line with the highest slope of the endothermal peak with the baseline.

 

Table 1: Melting point (DSC measurements)

Ident No.	Test item/ mg	Starting temperature / °C	Final test temperature / °C	Temperature range (melting) /°C	Onset / °C	Crucible	Observations after the measurement
35624	8.09	25	500	60 - 105	87.08	Aluminium with a hole	--
35626	10.22	25	150	65 - 100	89.11	Aluminium with a hole	Test item was a solidified clear melt

 

The test item had a melting range of 87 - 90 °C.

Conclusions:

The DSC measurements showed that the test item had a melting range of 87 - 90 °C.

Executive summary:

A study was conducted according to OECD test guideline 102, Regulation (EC) No 440/2008 method A.1. The melting range was determined by differential scanning calorimetry (DSC 25 - 500 °C). The test item and the reference are heated up from the starting temperature to the final temperature at a constant heating rate in a defined atmosphere (nitrogen). Open crucibles are used as containers for the test item and as empty reference crucible. The quantity of heat absorbed or released is measured and recorded. The DSC measurements showed that the test item had a melting range of 87 - 90 °C under atmospheric conditions.

Description of key information

A study was conducted according to OECD test guideline 102, Regulation (EC) No 440/2008 method A.1. The melting range was determined by differential scanning calorimetry (DSC 25 - 500 °C). The test item and the reference are heated up from the starting temperature to the final temperature at a constant heating rate in a defined atmosphere (nitrogen). Open crucibles are used as containers for the test item and as empty reference crucible. The quantity of heat absorbed or released is measured and recorded. The DSC measurements showed that the test item had a melting range of 87 - 90 °C under atmospheric conditions.