Registration Dossier
Registration Dossier
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EC number: 216-323-7 | CAS number: 1559-35-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- The study was conducted in the early days of GLP and prior to guidelines. So there is a general lack of detail in the reports, but the work was conducted in a superior facility, so the quality is not in question.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2-[(2-ethylhexyl)oxy]ethanol
- EC Number:
- 216-323-7
- EC Name:
- 2-[(2-ethylhexyl)oxy]ethanol
- Cas Number:
- 1559-35-9
- Molecular formula:
- C10H22O2
- IUPAC Name:
- 2-[(2-ethylhexyl)oxy]ethan-1-ol
Constituent 1
- Specific details on test material used for the study:
- None
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- 24 hour exposure to the depiliated abdomen under an occlusive wrap for 24 hours
- Duration of exposure:
- 24 hours
- Doses:
- 1
- No. of animals per sex per dose:
- not specified
- Control animals:
- no
- Details on study design:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 20 mL/kg bw
- Based on:
- test mat.
- Mortality:
- not specified
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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