Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Justification for type of information:
This work was done in the early days of GLP prior to guidelines in use. As such, study documentation is lacking, but the study was conducted at a superior facility, so the quality of the results are not in question

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[(2-ethylhexyl)oxy]ethanol
EC Number:
216-323-7
EC Name:
2-[(2-ethylhexyl)oxy]ethanol
Cas Number:
1559-35-9
Molecular formula:
C10H22O2
IUPAC Name:
2-[(2-ethylhexyl)oxy]ethan-1-ol
Specific details on test material used for the study:
Not provided

Test animals

Species:
guinea pig
Strain:
not specified
Details on test animals or test system and environmental conditions:
Not provided

Test system

Type of coverage:
occlusive
Preparation of test site:
other: Depiliated
Vehicle:
not specified
Controls:
no
Amount / concentration applied:
20 ml/kg
Duration of treatment / exposure:
24 hours
Observation period:
Not provided
Number of animals:
Not provided
Details on study design:
Not provided

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
not specified
Remarks on result:
not measured/tested
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
not specified
Remarks on result:
not measured/tested
Irritant / corrosive response data:
Not provided

Any other information on results incl. tables

Eye and skin irritation was conducted in 1980/1981, at the start of GLP. As a result, the reports are generally under-reported, as standards for report content had not yet been set. The report exists as more of a short summary of the findings, while the primary details of the conduct were kept in generic standard operating proceedures that were applicable to each type of study. As such, individual numeric evaluations were not available for these tests, and the results are reported out in a more general qualatative description. The values for the results provided here are not real and are only placeholders as TCC demanded some sort of entry, even if one was not available.

The laboratory where this work was conducted was the state of the art at the time, and was one of the top labs in the world. We have no reason to doubt the results of the studies, but the findings are not reported out in such way that they are very applicable to entry as a robust summary today.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The authors provided a statement that it was moderately irritating to skin