Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 249-385-9 | CAS number: 29043-70-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In the skin permeability study for dimethylbis(octadecyloxy)silane, conducted according to a draft OECD Test Guideline, and in compliance with GLP, no skin penetration of the test substance was observed.
Key value for chemical safety assessment
Additional information
The test item dimethylbis(octadecyloxy)silane was assessed for its potential to permeate porcine skin. The test item was tested at a concentration of 3 mg/ml suspended in ethanol/water (40% v/v).
Each donor chamber was filled with 1 ml of the test item suspended in ethanol/water (40% v/v). The same solvent was slowly pumped through the acceptor chambers with a flow rate of 1 to 2 ml per hour. The liquid leaving the acceptor chambers was collected and the fractions were
changed following the schedule below:
Experiments I and Il: 0; 0.5; l, 2; 4; 6; 8; and 24 hours following the application of the test item.
The conductivity across the skin samples of each chamber was measured at the same intervals. The blank samples (at 0 hours) were collected immediately prior to filling the donor chambers
at the maximal flow rate of the pumps. Air bubbles were observed in all of the acceptor chambers after 24 hours possibly blocking
some of the skin area. However, since the conductivity across the skin was hardly affected even after 24 hours, it was judged that the air bubbles did not have any relevant effect on the skin penetration. The samples were analysed by atom absorption spectroscopy.
No reproducible permeation of the skin occurred at any time point within the time frame of the experiments.
In conclusion, it can be stated that during the described permeability test and under the experimental conditions reported, the test item did not penetrate the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
