Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-652-6 | CAS number: 1634-02-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- The QSAR study clearly predicted that TBUT would not demonstrate bacterial mutagenic behaviour which is also corroborated with weight of evidence when compared to other thiuram structural analogues such as disulfram (tetraethyl rather than tetrabutyl structural analog).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tetrabutylthioperoxydicarbamic acid
- EC Number:
- 216-652-6
- EC Name:
- Tetrabutylthioperoxydicarbamic acid
- Cas Number:
- 1634-02-2
- Molecular formula:
- C18H36N2S4
- IUPAC Name:
- tetrabutylthioperoxydicarbamic acid
- Test material form:
- liquid
Constituent 1
Results and discussion
Test results
- Key result
- Genotoxicity:
- negative
- Remarks on result:
- no mutagenic potential (based on QSAR/QSPR prediction)
Applicant's summary and conclusion
- Conclusions:
- Based on the DEREK Nexus QSAR study compared to Lhasa reference set of Ames test data the substance showed unclassified for gentxicity endpoints.
- Executive summary:
QSAR studies predict no baterial mutagenicity behaviour and this is also correlates with other structurally similar compounds such as disulfram - CAS No. 97 -77 -8 (the diethyl thiuram analog).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
