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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Acute oral toxicity: LD50 ca. 1700 mg/kg bw; RL4; pre-GLP; rats showed clinical signs such as urine being yellower than normal, bad general condition, partly red crusted nose and snout, apathy as well as initial weight loss. During gross pathology, acute cardiac dilatation with congestive hyperemia, bloody gastric ulcerations and haematinized intestinal contents were observed.

Acute inhalation toxicity: mortality (rat): none; RL4, pre-GLP; no clinical signs or gross pathological evidence was observed. However, no exposure concentration was reported in the study report.

Acute dermal toxicity: discriminating dose >2500 mg/kg bw; RL4; pre-GLP; during the observation period, no death occurred and no clinical or gross pathological signs were observed.

Acute toxicity (other routes; intraperitoneal): LD50 (mouse) ca. 470 mg/kg bw; RL4; pre-GLP; clinical signs observed were slight apathy, partly dyspnoea, at high doses twitching and spring cramps. During gross pathology, intraabdominal substance precipitation was observed.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Principles of method if other than guideline:
no information available
GLP compliance:
no
Remarks:
Study conducted prior to implementation of GLP
Test type:
standard acute method
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 2-30%
Doses:
1700 mg/kg; observation after 7 days
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 700 mg/kg bw
Based on:
act. ingr.
Mortality:
none
Clinical signs:
urine yellower than normal; bad general condition, partly red crusted nose and snout and apathy
Body weight:
Initial weight loss
Gross pathology:
acute cardiac dilatation with congestive hyperemia, bloody gastric ulcerations, haematinized intestinal contents
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The oral LD50 of 3-hydroxy-2-methylquinoline-4-carboxylic acid in rats was ca. 1700 mg/kg bw.
Executive summary:

In an acute oral toxicity study, rats were given a single oral dose of 3-hydroxy-2-methylquinoline-4-carboxylic acid in aqueous suspension with carboxymethyl cellulose and were then observed for 7 days.

During the observation period, clinical signs were urine being yellower than normal, bad general condition, partly red crusted nose and snout, apathy as well as initial weight loss. During gross pathology, acute cardiac dilatation with congestive hyperemia, bloody gastric ulcerations and haematinized intestinal contents were observed.

Oral LD50 (rats) ca. 1700 mg/kg bw

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 700 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Principles of method if other than guideline:
No information provided
GLP compliance:
no
Remarks:
Study conducted prior to implementation of GLP
Test type:
concentration x time method
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
inhalation: dust
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Temperature in air chamber: 20°C
VEHICLE
- Composition of vehicle: air (not further specified)
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
>= 3 - <= 480 min
Concentrations:
not specified (air passed through 5 cm layer of test substance)
No. of animals per sex per dose:
12 animals (sex not specified)
Control animals:
not specified
Remarks on result:
other: No LC50 determined
Mortality:
none
Clinical signs:
other: none
Body weight:
not specified
Gross pathology:
none
Interpretation of results:
study cannot be used for classification
Conclusions:
Inhalation of 3-hydroxy-2-methylquinoline-4-carboxylic acid showed no effects.
Executive summary:

In an acute inhalation to 3-hydroxy-2-methylquinoline-4-carboxylic acid in air for up to 8 hours.

During the observation period, no death occurred and no clinical signs or gross pathological evidence was observed.

Mortality (rats): none

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Quality of whole database:
An inhalation study (concentration x time method) was conducted in rats. No information about the exposure concentration was reported. Therefore the study is not suitable for assessment and classification.

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Principles of method if other than guideline:
no information available
GLP compliance:
no
Remarks:
Study conducted prior to implementation of GLP
Species:
rat
Strain:
not specified
Sex:
not specified
Type of coverage:
not specified
Vehicle:
water
Details on dermal exposure:
TEST MATERIAL
- Concentration: 50% (aqueous grinding)
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 500 mg/kg bw
Based on:
act. ingr.
Mortality:
none
Clinical signs:
none
Gross pathology:
none
Interpretation of results:
GHS criteria not met
Conclusions:
The dermal LD50 of 3-hydroxy-2-methylquinoline-4-carboxylic acid in rats was > 2500 mg/kg bw.
Executive summary:

In an acute toxicity study, rats were given a single dose of 50% 3-hydroxy-2-methylquinoline-4-carboxylic acid (aqueous grinding) at a dose of 2500 mg/kg bw and were observed for 14 days.

During the observation period, no death occurred and no clinical or gross pathological signs were observed.

Dermal LD50 (rats) > 2500 mg/kg bw

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
2 500 mg/kg bw

Additional information

Acute toxicity (other routes; intraperitoneal); adverse effect observed; LD50 ca. 470 mg/kg bw

Justification for classification or non-classification

Acute oral toxicity

Based on relevant and adequate data, the test substance has to be classified and labelled according to the CLP Regulation (EC) No 1272/2008 with respect to acute oral toxicity, Category 4.

Acute inhalation toxicity

No exposure concentration was reported in the study report and no LC50 was determined. Therefore the study cannot be used for classification.

Acute dermal toxicity

Based on relevant and adequate data, the test substance does not need to be classified and labelled according to the CLP Regulation (EC) No 1272/2008 with respect to acute dermal toxicity.