Registration Dossier
Registration Dossier
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EC number: 204-198-1 | CAS number: 117-57-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- no information available
- GLP compliance:
- no
- Remarks:
- Study conducted prior to implementation of GLP
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- EC Number:
- 204-198-1
- EC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- Cas Number:
- 117-57-7
- Molecular formula:
- C11H9NO3
- IUPAC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 2-30% - Doses:
- 1700 mg/kg; observation after 7 days
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 700 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- none
- Clinical signs:
- urine yellower than normal; bad general condition, partly red crusted nose and snout and apathy
- Body weight:
- Initial weight loss
- Gross pathology:
- acute cardiac dilatation with congestive hyperemia, bloody gastric ulcerations, haematinized intestinal contents
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The oral LD50 of 3-hydroxy-2-methylquinoline-4-carboxylic acid in rats was ca. 1700 mg/kg bw.
- Executive summary:
In an acute oral toxicity study, rats were given a single oral dose of 3-hydroxy-2-methylquinoline-4-carboxylic acid in aqueous suspension with carboxymethyl cellulose and were then observed for 7 days.
During the observation period, clinical signs were urine being yellower than normal, bad general condition, partly red crusted nose and snout, apathy as well as initial weight loss. During gross pathology, acute cardiac dilatation with congestive hyperemia, bloody gastric ulcerations and haematinized intestinal contents were observed.
Oral LD50 (rats) ca. 1700 mg/kg bw
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