α-d-Glucopyranoside, β-d-fructofuranosyl, mono, di, and tridodecanoate esters

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: OECD Guideline 105

Deviations:

yes

Remarks:

OECD Guideline 105 is a water solubility test. To determine the solubility of the substance in octanol, a similar protocol was used using octanol as the solvent.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Test material form:

solid: flakes

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Mitsubishi-Chemical Food Corporation;

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: in refrigerator

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final preparation of a solid: pulverized

Results and discussion

Solubility in organic solvents / fat solubility

Key result

Medium:

n-octanol

Solubility:

>= 1 000 g/L

Temp.:

20 °C

Remarks on result:

other: miscible in octanol

Test substance stable:

not determined

Details on results:

The pre-test solubility was incorrect as the test substance dissolution kinetics were slower than foreseen.
No precipitation was seen even after 10 g of test substance had been added. The solution became very viscous and could no longer be stirred.

Applicant's summary and conclusion

Conclusions:

The test substance is completely miscible in octanol.

Executive summary:

The solubility of the test substance was determined in a study performed similarly to a OECD Guideline 105 water solubility study, but octanol was used as the solvent. Up to 10 g of test substance was added to 10 mL of water. The liquid became very viscous, but no precipitate was observed. The solubility of the test substance in octanol is at least 1 kg/L octanol. The test substance is completely miscible in octanol at 20 degrees C.